Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dnaDDNA replication protein DnaD; Initiation of chromosome replication (primosome component). (215 aa)    
Predicted Functional Partners:
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
  
 0.954
dnaI
Primosomal protein DnaI.
 
  
 0.910
dnaB
Chromosome replication initiation/membrane attachment protein DnaB.
 
   
 0.862
dinG
ATP-dependent DNA helicase DinG; 3'-5' exonuclease.
 
  
 0.841
addB
ATP-dependent deoxyribonuclease subunit B; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity; Belongs to the helicase family. AddB/RexB type 2 subfamily.
 
     0.747
Ldb1590
Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms.
  
     0.701
Ldb1628
Conserved hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.
  
     0.673
Ldb1604
Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms; Belongs to the UPF0473 family.
  
     0.660
ftsK
Cell division protein FtsK; Belongs to the FtsK/SpoIIIE/SftA family.
  
  
 0.644
addA
ATP-dependent deoxyribonuclease subunit A; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily.
 
    0.626
Your Current Organism:
Lactobacillus delbrueckii
NCBI taxonomy Id: 390333
Other names: L. delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, Lactobacillus delbrueckii subsp. bulgaricus DSM 20081
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