Ldb1010 protein (Lactobacillus delbrueckii) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

Ldb1010

Conserved hypothetical protein (fragment); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (333 aa)

Predicted Functional Partners:

ldh

0.981

Ldb0094

0.970

pyk

0.963

Ldb2021

0.930

ldhA

0.921

pox1

0.905

Ldb1011

0.633

gapN

0.525

Ldb1707

0.503

Ldb0813

0.449

Your Current Organism:

Lactobacillus delbrueckii

NCBI taxonomy Id: 390333
Other names: L. delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, Lactobacillus delbrueckii subsp. bulgaricus DSM 20081

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ldb0094	Ldb1010	Ldb0094	Ldb1010	L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily.	Conserved hypothetical protein (fragment); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.970
Ldb0094	Ldb1707	Ldb0094	Ldb1707	L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily.	Acetaldehyde dehydrogenase.	0.531
Ldb0094	Ldb2021	Ldb0094	Ldb2021	L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily.	D-isomer specific 2-hydroxyacid dehydrogenase.	0.970
Ldb0094	gapN	Ldb0094	Ldb1179	L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily.	Homoserine O-succinyltransferase (fragment); Belongs to the aldehyde dehydrogenase family.	0.848
Ldb0094	ldh	Ldb0094	Ldb0120	L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily.	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate.	0.934
Ldb0094	ldhA	Ldb0094	Ldb0101	L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily.	D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.970
Ldb0094	pox1	Ldb0094	Ldb2213	L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily.	Pyruvate oxidase; Belongs to the TPP enzyme family.	0.927
Ldb0094	pyk	Ldb0094	Ldb0839	L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.978
Ldb0813	Ldb1010	Ldb0813	Ldb1010	D-isomer specific 2-hydroxyacid dehydrogenase.	Conserved hypothetical protein (fragment); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.449
Ldb0813	Ldb1707	Ldb0813	Ldb1707	D-isomer specific 2-hydroxyacid dehydrogenase.	Acetaldehyde dehydrogenase.	0.503
Ldb0813	Ldb2021	Ldb0813	Ldb2021	D-isomer specific 2-hydroxyacid dehydrogenase.	D-isomer specific 2-hydroxyacid dehydrogenase.	0.475
Ldb0813	ldhA	Ldb0813	Ldb0101	D-isomer specific 2-hydroxyacid dehydrogenase.	D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.442
Ldb0813	pyk	Ldb0813	Ldb0839	D-isomer specific 2-hydroxyacid dehydrogenase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.687
Ldb1010	Ldb0094	Ldb1010	Ldb0094	Conserved hypothetical protein (fragment); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.970
Ldb1010	Ldb0813	Ldb1010	Ldb0813	Conserved hypothetical protein (fragment); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	D-isomer specific 2-hydroxyacid dehydrogenase.	0.449
Ldb1010	Ldb1011	Ldb1010	Ldb1011	Conserved hypothetical protein (fragment); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Putative acylaminoacyl-peptidase.	0.633
Ldb1010	Ldb1707	Ldb1010	Ldb1707	Conserved hypothetical protein (fragment); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Acetaldehyde dehydrogenase.	0.503
Ldb1010	Ldb2021	Ldb1010	Ldb2021	Conserved hypothetical protein (fragment); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	D-isomer specific 2-hydroxyacid dehydrogenase.	0.930
Ldb1010	gapN	Ldb1010	Ldb1179	Conserved hypothetical protein (fragment); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Homoserine O-succinyltransferase (fragment); Belongs to the aldehyde dehydrogenase family.	0.525
Ldb1010	ldh	Ldb1010	Ldb0120	Conserved hypothetical protein (fragment); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate.	0.981

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.804

expected number of edges:

10

PPI enrichment p-value:

1.45e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007097

Nuclear migration

6 of 29

2.49

4.89

2.29e-10

GO:0051642

Centrosome localization

5 of 34

2.35

3.6

7.49e-08

GO:1902017

Regulation of cilium assembly

4 of 46

2.12

2.24

3.54e-05

GO:0046907

Intracellular transport

7 of 997

1.03

0.88

0.00086

GO:0033043

Regulation of organelle organization

5 of 761

1.0

0.51

0.0484

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140444

Cytoskeleton-nuclear membrane anchor activity

5 of 11

2.84

4.97

5.07e-10

GO:0060090

Molecular adaptor activity

6 of 308

1.47

1.74

1.64e-05

GO:0051015

Actin filament binding

4 of 212

1.45

1.03

0.0045

GO:0008092

Cytoskeletal protein binding

5 of 842

0.95

0.5

0.0479

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034993

Meiotic nuclear membrane microtubule tethering complex

5 of 14

2.73

4.85

6.70e-10

GO:0005640

Nuclear outer membrane

4 of 24

2.4

3.27

4.65e-07

GO:0031965

Nuclear membrane

6 of 179

1.7

2.6

2.05e-07

GO:0030017

Sarcomere

4 of 143

1.63

1.54

0.00031

GO:0098590

Plasma membrane region

6 of 773

1.07

0.97

0.00040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19246

Cytoskeleton-nuclear membrane anchor activity, and Lamin tail domain superfamily

6 of 18

2.7

5.78

7.80e-12

CL:19248

Cytoskeleton-nuclear membrane anchor activity

5 of 10

2.88

5.31

1.21e-10

CL:14822

Mixed, incl. EH domain, and T-complex protein 10, C-terminal domain superfamily

4 of 11

2.74

3.78

8.69e-08

CL:19250

Cytoskeleton-nuclear membrane anchor activity

2 of 5

2.78

1.52

0.0017

CL:14825

T-complex protein 10, C-terminal domain superfamily, and EH domain

2 of 5

2.78

1.52

0.0017

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1474165

Reproduction

5 of 42

2.25

3.45

1.10e-07

MAP-1640170

Cell Cycle

6 of 665

1.13

0.94

0.0014

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

4 of 225

1.43

1.5

9.65e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034993

Meiotic nuclear membrane microtubule tethering complex

5 of 12

2.8

4.99

4.16e-10

GOCC:0031965

Nuclear membrane

4 of 68

1.95

2.18

2.68e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR012315

KASH domain

2 of 3

3.0

0.9

0.0241

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01249

Nuclear envelope localisation domain

2 of 3

3.0

1.4

0.0029

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