Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hsdMType I restriction-modification system, modification subunit. (532 aa)    
Predicted Functional Partners:
hsdR
Conserved hypothetical protein (fragment); Subunit R is required for both nuclease and ATPase activities, but not for modification.
  
 0.998
hsdS1
Type I restriction-modification system, specificity subunit.
 
 0.998
hsdS2
Type I restriction-modification system, specificity subunit.
 
 
 0.989
rplL
50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.
    
 
 0.618
Ldb0474
Putative restriction endonuclease.
  
  
 0.511
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.494
Ldb1346
Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms; Belongs to the methyltransferase superfamily.
     
 0.494
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.479
rpsI
30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.
     
 0.467
Ldb1232
Putative helicase.
     
 0.460
Your Current Organism:
Lactobacillus delbrueckii
NCBI taxonomy Id: 390333
Other names: L. delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, Lactobacillus delbrueckii subsp. bulgaricus DSM 20081
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