| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpC | dnaJ | Ldb0383 | Ldb1312 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interac [...] | 0.751 |
| clpC | dnaK | Ldb0383 | Ldb1313 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK (heat shock protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.912 |
| clpC | groEL | Ldb0383 | Ldb1617 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 60 kDa chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.575 |
| clpC | groES | Ldb0383 | Ldb1618 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 10 kDa chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.649 |
| clpC | grpE | Ldb0383 | Ldb1314 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone protein GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Se [...] | 0.728 |
| clpC | hrcA | Ldb0383 | Ldb1315 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.407 |
| clpE | dnaJ | Ldb0574 | Ldb1312 | ATP-dependent Clp protease, ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interac [...] | 0.786 |
| clpE | dnaK | Ldb0574 | Ldb1313 | ATP-dependent Clp protease, ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK (heat shock protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.872 |
| clpE | groEL | Ldb0574 | Ldb1617 | ATP-dependent Clp protease, ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | 60 kDa chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.558 |
| clpE | groES | Ldb0574 | Ldb1618 | ATP-dependent Clp protease, ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | 10 kDa chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.627 |
| clpE | grpE | Ldb0574 | Ldb1314 | ATP-dependent Clp protease, ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Chaperone protein GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Se [...] | 0.772 |
| clpE | hrcA | Ldb0574 | Ldb1315 | ATP-dependent Clp protease, ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.455 |
| clpL | dnaJ | Ldb2102 | Ldb1312 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interac [...] | 0.751 |
| clpL | dnaK | Ldb2102 | Ldb1313 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK (heat shock protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.872 |
| clpL | groEL | Ldb2102 | Ldb1617 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 60 kDa chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.558 |
| clpL | groES | Ldb2102 | Ldb1618 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 10 kDa chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.570 |
| clpL | grpE | Ldb2102 | Ldb1314 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone protein GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Se [...] | 0.764 |
| clpL | hrcA | Ldb2102 | Ldb1315 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.460 |
| dnaJ | clpC | Ldb1312 | Ldb0383 | Chaperone protein DnaJ (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interac [...] | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.751 |
| dnaJ | clpE | Ldb1312 | Ldb0574 | Chaperone protein DnaJ (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interac [...] | ATP-dependent Clp protease, ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | 0.786 |
