Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pyrC1Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (425 aa)    
Predicted Functional Partners:
pyrB1
Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 0.999
pyrD1
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
 
 0.993
pyrD2
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.991
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
  
 0.989
carA1,
Carbamoyl-phosphate synthase, large chain (fragment); Similar to ISL5 transposase; Belongs to the CarA family.
  
 0.989
pyrF
Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
  
 0.987
carB3,
Carbamoyl-phosphate synthase, large chain; Belongs to the CarB family.
 
 
 0.985
pyrP
Uracil permease.
  
  
 0.980
carA3,
Carbamoyl-phosphate synthase, small chain.
 
  
 0.972
carA2a
Carbamoyl-phosphate synthase, large chain (fragment); Alternative gene name: pyrAB2a (fragm1); Belongs to the CarA family.
 
  
 0.972
Your Current Organism:
Lactobacillus delbrueckii
NCBI taxonomy Id: 390333
Other names: L. delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, Lactobacillus delbrueckii subsp. bulgaricus DSM 20081
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.