node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Smal_1597 | dnaJ | Smal_1597 | Smal_1601 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.424 |
Smal_1597 | dnaK | Smal_1597 | Smal_1600 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.482 |
Smal_1597 | grpE | Smal_1597 | Smal_1599 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.566 |
Smal_1597 | hrcA | Smal_1597 | Smal_1598 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.745 |
Smal_2501 | Smal_2937 | Smal_2501 | Smal_2937 | PFAM: peptidase S14 ClpP; KEGG: bmu:Bmul_3866 peptidase S14 ClpP; Belongs to the peptidase S14 family. | KEGG: xac:XAC1357 heat shock protein. | 0.558 |
Smal_2501 | dnaJ | Smal_2501 | Smal_1601 | PFAM: peptidase S14 ClpP; KEGG: bmu:Bmul_3866 peptidase S14 ClpP; Belongs to the peptidase S14 family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.442 |
Smal_2501 | dnaK | Smal_2501 | Smal_1600 | PFAM: peptidase S14 ClpP; KEGG: bmu:Bmul_3866 peptidase S14 ClpP; Belongs to the peptidase S14 family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.599 |
Smal_2501 | groL | Smal_2501 | Smal_3626 | PFAM: peptidase S14 ClpP; KEGG: bmu:Bmul_3866 peptidase S14 ClpP; Belongs to the peptidase S14 family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.527 |
Smal_2501 | grpE | Smal_2501 | Smal_1599 | PFAM: peptidase S14 ClpP; KEGG: bmu:Bmul_3866 peptidase S14 ClpP; Belongs to the peptidase S14 family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.611 |
Smal_2501 | hrcA | Smal_2501 | Smal_1598 | PFAM: peptidase S14 ClpP; KEGG: bmu:Bmul_3866 peptidase S14 ClpP; Belongs to the peptidase S14 family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.704 |
Smal_2937 | Smal_2501 | Smal_2937 | Smal_2501 | KEGG: xac:XAC1357 heat shock protein. | PFAM: peptidase S14 ClpP; KEGG: bmu:Bmul_3866 peptidase S14 ClpP; Belongs to the peptidase S14 family. | 0.558 |
Smal_2937 | Smal_3019 | Smal_2937 | Smal_3019 | KEGG: xac:XAC1357 heat shock protein. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: xcb:XC_3198 curved DNA binding protein. | 0.972 |
Smal_2937 | clpP | Smal_2937 | Smal_0836 | KEGG: xac:XAC1357 heat shock protein. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.558 |
Smal_2937 | clpP-2 | Smal_2937 | Smal_2790 | KEGG: xac:XAC1357 heat shock protein. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.558 |
Smal_2937 | dnaJ | Smal_2937 | Smal_1601 | KEGG: xac:XAC1357 heat shock protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.972 |
Smal_2937 | groL | Smal_2937 | Smal_3626 | KEGG: xac:XAC1357 heat shock protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.958 |
Smal_2937 | grpE | Smal_2937 | Smal_1599 | KEGG: xac:XAC1357 heat shock protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.975 |
Smal_2937 | hrcA | Smal_2937 | Smal_1598 | KEGG: xac:XAC1357 heat shock protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.849 |
Smal_3019 | Smal_2937 | Smal_3019 | Smal_2937 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: xcb:XC_3198 curved DNA binding protein. | KEGG: xac:XAC1357 heat shock protein. | 0.972 |
Smal_3019 | dnaK | Smal_3019 | Smal_1600 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: xcb:XC_3198 curved DNA binding protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |