STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (126 aa)    
Predicted Functional Partners:
Tmel_1425
PFAM: CBS domain containing protein; phosphoesterase, RecJ domain protein; Polynucleotide adenylyltransferase region; phosphoesterase, DHHA1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
  
 0.838
Tmel_0525
TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3.
       0.803
Tmel_0526
Hypothetical protein.
       0.788
dapB
Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
  
    0.782
asnS
TIGRFAM: asparaginyl-tRNA synthetase; PFAM: tRNA synthetase, class II (D, K and N); nucleic acid binding, OB-fold, tRNA/helicase-type.
       0.758
Tmel_0523
PFAM: major facilitator superfamily MFS_1.
       0.585
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.442
tpiA
Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
      
 0.406
pgk
PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
      
 0.406
Tmel_1606
TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase.
  
  
 0.404
Your Current Organism:
Thermosipho melanesiensis
NCBI taxonomy Id: 391009
Other names: T. melanesiensis BI429, Thermosipho melanesiensis BI429, Thermosipho melanesiensis str. BI429, Thermosipho melanesiensis strain BI429
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