node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tmel_0123 | Tmel_1766 | Tmel_0123 | Tmel_1766 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | PFAM: CMP/dCMP deaminase, zinc-binding. | 0.906 |
Tmel_0123 | surE | Tmel_0123 | Tmel_0836 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.915 |
Tmel_0123 | tdk | Tmel_0123 | Tmel_1206 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | PFAM: thymidine kinase. | 0.916 |
Tmel_0123 | thyX | Tmel_0123 | Tmel_1909 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.900 |
Tmel_0123 | tmk | Tmel_0123 | Tmel_0927 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.912 |
Tmel_0606 | ndk | Tmel_0606 | Tmel_0381 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.921 |
Tmel_0606 | polA | Tmel_0606 | Tmel_1917 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.724 |
Tmel_0606 | tdk | Tmel_0606 | Tmel_1206 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | PFAM: thymidine kinase. | 0.496 |
Tmel_0606 | tmk | Tmel_0606 | Tmel_0927 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.943 |
Tmel_1766 | Tmel_0123 | Tmel_1766 | Tmel_0123 | PFAM: CMP/dCMP deaminase, zinc-binding. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | 0.906 |
Tmel_1766 | polA | Tmel_1766 | Tmel_1917 | PFAM: CMP/dCMP deaminase, zinc-binding. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.428 |
Tmel_1766 | surE | Tmel_1766 | Tmel_0836 | PFAM: CMP/dCMP deaminase, zinc-binding. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Tmel_1766 | tdk | Tmel_1766 | Tmel_1206 | PFAM: CMP/dCMP deaminase, zinc-binding. | PFAM: thymidine kinase. | 0.933 |
Tmel_1766 | thyX | Tmel_1766 | Tmel_1909 | PFAM: CMP/dCMP deaminase, zinc-binding. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.914 |
Tmel_1766 | tmk | Tmel_1766 | Tmel_0927 | PFAM: CMP/dCMP deaminase, zinc-binding. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.933 |
coaX | tmk | Tmel_1367 | Tmel_0927 | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.605 |
ndk | Tmel_0606 | Tmel_0381 | Tmel_0606 | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.921 |
ndk | rpsB | Tmel_0381 | Tmel_0926 | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | PFAM: ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | 0.987 |
ndk | tmk | Tmel_0381 | Tmel_0927 | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.934 |
polA | Tmel_0606 | Tmel_1917 | Tmel_0606 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.724 |