STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sare_1100PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: stp:Strop_1207 thiamine pyrophosphate enzyme domain protein TPP-binding; Belongs to the TPP enzyme family. (540 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.989
Sare_1124
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: stp:Strop_1234 acetolactate synthase, small subunit.
 
 
 0.976
Sare_1129
PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: stp:Strop_1239 3-isopropylmalate dehydrogenase.
 
 0.965
Sare_0646
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: stp:Strop_0699 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein.
  
 
 0.937
Sare_0865
TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: stp:Strop_0922 threonine dehydratase.
  
 0.929
Sare_0645
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: stp:Strop_0698 thiamine pyrophosphate enzyme domain protein TPP-binding.
    
 0.908
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.900
Sare_1133
TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: stp:Strop_1243 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.876
Sare_3238
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mxa:MXAN_3857 pyruvate dehydrogenase; Belongs to the TPP enzyme family.
  
  
0.835
Sare_1406
Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: stp:Strop_1448 malate dehydrogenase (oxaloacetate-decarboxylating).
  
 
 0.834
Your Current Organism:
Salinispora arenicola
NCBI taxonomy Id: 391037
Other names: S. arenicola CNS-205, Salinispora arenicola CNS-205, Salinispora arenicola str. CNS-205, Salinispora arenicola strain CNS-205
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.