STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sare_1365PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; DEAD/H associated domain protein; SMART: DEAD-like helicases; KEGG: stp:Strop_1406 DEAD/H associated domain protein. (1561 aa)    
Predicted Functional Partners:
Sare_1363
Formamidopyrimidine-DNA glycolase, H2TH DNA binding; PFAM: zinc finger Fpg domain protein; Formamidopyrimidine-DNA glycosylase catalytic domain protein; Formamidopyrimidine-DNA glycolase, H2TH DNA binding; KEGG: aau:AAur_0780 putative formamidopyrimidine-DNA glycosylase; Belongs to the FPG family.
 
  
 0.951
Sare_3518
KEGG: stp:Strop_3286 DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Excinuclease ABC C subunit domain protein; Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease.
  
  
 0.784
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
   
    0.719
Sare_1364
PFAM: protein of unknown function DUF62; KEGG: stp:Strop_1405 protein of unknown function DUF62.
       0.633
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 0.537
Sare_5005
DNA-(apurinic or apyrimidinic site) lyase; PFAM: Formamidopyrimidine-DNA glycosylase catalytic domain protein; Formamidopyrimidine-DNA glycolase, H2TH DNA binding; KEGG: stp:Strop_4491 DNA-(apurinic or apyrimidinic site) lyase; Belongs to the FPG family.
  
  
 0.537
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.534
Sare_1492
KEGG: stp:Strop_1548 hypothetical protein.
 
  
 0.514
Sare_1366
KEGG: stp:Strop_1407 hypothetical protein.
       0.511
Sare_1213
PFAM: Bifunctional DNA primase/polymerase; KEGG: fra:Francci3_1201 conserved hypothetical protein 2SC10A7.05c.
   
    0.479
Your Current Organism:
Salinispora arenicola
NCBI taxonomy Id: 391037
Other names: S. arenicola CNS-205, Salinispora arenicola CNS-205, Salinispora arenicola str. CNS-205, Salinispora arenicola strain CNS-205
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.