node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bphy_0621 | Bphy_5008 | Bphy_0621 | Bphy_5008 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | 0.414 |
Bphy_0621 | dxr | Bphy_0621 | Bphy_1332 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.409 |
Bphy_0621 | ispD | Bphy_0621 | Bphy_0998 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.527 |
Bphy_0621 | ispE | Bphy_0621 | Bphy_0316 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.408 |
Bphy_0621 | ispG | Bphy_0621 | Bphy_1420 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.526 |
Bphy_0621 | pdxJ | Bphy_0621 | Bphy_0844 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.528 |
Bphy_0621 | ribB-2 | Bphy_0621 | Bphy_0619 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
Bphy_5007 | Bphy_5008 | Bphy_5007 | Bphy_5008 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: reu:Reut_B4490 acetolactate synthase, large subunit, biosynthetic type. | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | 0.441 |
Bphy_5007 | Bphy_5009 | Bphy_5007 | Bphy_5009 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: reu:Reut_B4490 acetolactate synthase, large subunit, biosynthetic type. | Putative transcriptional regulator, ArsR family; SMART: regulatory protein ArsR; KEGG: psb:Psyr_4051 regulatory protein, ArsR. | 0.441 |
Bphy_5008 | Bphy_0621 | Bphy_5008 | Bphy_0621 | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.414 |
Bphy_5008 | Bphy_5007 | Bphy_5008 | Bphy_5007 | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: reu:Reut_B4490 acetolactate synthase, large subunit, biosynthetic type. | 0.441 |
Bphy_5008 | Bphy_5009 | Bphy_5008 | Bphy_5009 | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | Putative transcriptional regulator, ArsR family; SMART: regulatory protein ArsR; KEGG: psb:Psyr_4051 regulatory protein, ArsR. | 0.779 |
Bphy_5008 | dxr | Bphy_5008 | Bphy_1332 | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.705 |
Bphy_5008 | ispD | Bphy_5008 | Bphy_0998 | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.457 |
Bphy_5008 | ispE | Bphy_5008 | Bphy_0316 | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.415 |
Bphy_5008 | ispG | Bphy_5008 | Bphy_1420 | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.420 |
Bphy_5008 | pdxJ | Bphy_5008 | Bphy_0844 | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.583 |
Bphy_5008 | ribB-2 | Bphy_5008 | Bphy_0619 | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.509 |
Bphy_5008 | thiG | Bphy_5008 | Bphy_2772 | KEGG: rso:RSc2221 1-deoxy-D-xylulose-5-phosphate synthase. | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.584 |
Bphy_5009 | Bphy_5007 | Bphy_5009 | Bphy_5007 | Putative transcriptional regulator, ArsR family; SMART: regulatory protein ArsR; KEGG: psb:Psyr_4051 regulatory protein, ArsR. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: reu:Reut_B4490 acetolactate synthase, large subunit, biosynthetic type. | 0.441 |