STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC111140505NEDD8. (81 aa)    
Predicted Functional Partners:
LOC111139876
NEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.998
LOC111144033
NEDD8-activating enzyme E1 catalytic subunit isoform X1.
   
 0.996
LOC111154336
Cullin-1; Belongs to the cullin family.
    
 0.991
LOC111157501
E3 ubiquitin-protein ligase RBX1 isoform X1.
   
 0.989
LOC111153265
Sentrin-specific protease 8.
    
 0.988
LOC111144277
NEDD8-conjugating enzyme UBE2F; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.987
LOC111152806
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
   
 0.985
LOC111153822
Cullin-5; Belongs to the cullin family.
    
 0.963
LOC111141245
S-phase kinase-associated protein 1 isoform X1; Belongs to the SKP1 family.
   
 0.958
LOC111155593
Cullin-2 isoform X1; Belongs to the cullin family.
    
 0.958
Your Current Organism:
Enhydra lutris
NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.