node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP88976.1 | ABP89723.1 | SSU05_0002 | SSU05_0757 | DNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...] | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | 0.531 |
ABP88976.1 | ABP89724.1 | SSU05_0002 | SSU05_0758 | DNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...] | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | 0.531 |
ABP88976.1 | polA | SSU05_0002 | SSU05_1378 | DNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...] | DNA polymerase I - 3'-5' exonuclease and polymerase domain; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.998 |
ABP88976.1 | recF | SSU05_0002 | SSU05_2182 | DNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...] | Recombinational DNA repair ATPase (RecF pathway); The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.837 |
ABP89349.1 | ABP89723.1 | SSU05_0382 | SSU05_0757 | Hypothetical protein. | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | 0.542 |
ABP89349.1 | ABP89724.1 | SSU05_0382 | SSU05_0758 | Hypothetical protein. | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | 0.542 |
ABP89349.1 | polA | SSU05_0382 | SSU05_1378 | Hypothetical protein. | DNA polymerase I - 3'-5' exonuclease and polymerase domain; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.633 |
ABP89723.1 | ABP88976.1 | SSU05_0757 | SSU05_0002 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | DNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...] | 0.531 |
ABP89723.1 | ABP89349.1 | SSU05_0757 | SSU05_0382 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | Hypothetical protein. | 0.542 |
ABP89723.1 | ABP89724.1 | SSU05_0757 | SSU05_0758 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | 0.990 |
ABP89723.1 | ABP89725.1 | SSU05_0757 | SSU05_0759 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | ABC-type phosphate transport system, ATPase component. | 0.559 |
ABP89723.1 | ABP90761.1 | SSU05_0757 | SSU05_1795 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | Histone acetyltransferase HPA2 and related acetyltransferases. | 0.588 |
ABP89723.1 | gyrA | SSU05_0757 | SSU05_1075 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.954 |
ABP89723.1 | parC | SSU05_0757 | SSU05_0764 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | 0.964 |
ABP89723.1 | polA | SSU05_0757 | SSU05_1378 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | DNA polymerase I - 3'-5' exonuclease and polymerase domain; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.593 |
ABP89723.1 | recF | SSU05_0757 | SSU05_2182 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | Recombinational DNA repair ATPase (RecF pathway); The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.525 |
ABP89723.1 | smc | SSU05_0757 | SSU05_1190 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | Chromosome segregation ATPase; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.448 |
ABP89724.1 | ABP88976.1 | SSU05_0758 | SSU05_0002 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | DNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...] | 0.531 |
ABP89724.1 | ABP89349.1 | SSU05_0758 | SSU05_0382 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | Hypothetical protein. | 0.542 |
ABP89724.1 | ABP89723.1 | SSU05_0758 | SSU05_0757 | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. | 0.990 |