node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP89801.1 | glyA | SSU05_0835 | SSU05_0852 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
ABP89801.1 | thyA | SSU05_0835 | SSU05_0834 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.996 |
ABP89812.1 | ABP90504.1 | SSU05_0846 | SSU05_1538 | Thymidine kinase. | Putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.903 |
ABP89812.1 | ABP90588.1 | SSU05_0846 | SSU05_1622 | Thymidine kinase. | Deoxycytidylate deaminase. | 0.926 |
ABP89812.1 | ABP91001.1 | SSU05_0846 | SSU05_2035 | Thymidine kinase. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.953 |
ABP89812.1 | ABP91082.1 | SSU05_0846 | SSU05_2116 | Thymidine kinase. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.903 |
ABP89812.1 | thyA | SSU05_0846 | SSU05_0834 | Thymidine kinase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.952 |
ABP89812.1 | tmk | SSU05_0846 | SSU05_0661 | Thymidine kinase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.927 |
ABP90504.1 | ABP89812.1 | SSU05_1538 | SSU05_0846 | Putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidine kinase. | 0.903 |
ABP90504.1 | ABP90588.1 | SSU05_1538 | SSU05_1622 | Putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Deoxycytidylate deaminase. | 0.904 |
ABP90504.1 | ABP91001.1 | SSU05_1538 | SSU05_2035 | Putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
ABP90504.1 | ABP91082.1 | SSU05_1538 | SSU05_2116 | Putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.942 |
ABP90504.1 | thyA | SSU05_1538 | SSU05_0834 | Putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
ABP90504.1 | tmk | SSU05_1538 | SSU05_0661 | Putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.911 |
ABP90588.1 | ABP89812.1 | SSU05_1622 | SSU05_0846 | Deoxycytidylate deaminase. | Thymidine kinase. | 0.926 |
ABP90588.1 | ABP90504.1 | SSU05_1622 | SSU05_1538 | Deoxycytidylate deaminase. | Putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.904 |
ABP90588.1 | ABP91001.1 | SSU05_1622 | SSU05_2035 | Deoxycytidylate deaminase. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.947 |
ABP90588.1 | ABP91082.1 | SSU05_1622 | SSU05_2116 | Deoxycytidylate deaminase. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.904 |
ABP90588.1 | thyA | SSU05_1622 | SSU05_0834 | Deoxycytidylate deaminase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.942 |
ABP90588.1 | tmk | SSU05_1622 | SSU05_0661 | Deoxycytidylate deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.932 |