EDP94827.1 protein (Kordia algicida) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

EDP94827.1

Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins. (377 aa)

Predicted Functional Partners:

EDP95633.1

0.685

EDP95181.1

0.653

EDP94923.1

0.653

EDP98551.1

0.653

EDP95599.1

0.653

EDP95634.1

0.653

EDP94826.1

0.594

EDP94828.1

0.527

EDP95497.1

0.526

EDP98159.1

0.519

Your Current Organism:

Kordia algicida

NCBI taxonomy Id: 391587
Other names: K. algicida OT-1, Kordia algicida NBRC 10036, Kordia algicida OT-1, Kordia algicida str. OT-1, Kordia algicida strain OT-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDP94826.1	EDP94827.1	KAOT1_01330	KAOT1_01335	Hypothetical protein; COG0457 FOG: TPR repeat.	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	0.594
EDP94826.1	EDP94828.1	KAOT1_01330	KAOT1_01340	Hypothetical protein; COG0457 FOG: TPR repeat.	Hypothetical protein.	0.417
EDP94827.1	EDP94826.1	KAOT1_01335	KAOT1_01330	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	Hypothetical protein; COG0457 FOG: TPR repeat.	0.594
EDP94827.1	EDP94828.1	KAOT1_01335	KAOT1_01340	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	Hypothetical protein.	0.527
EDP94827.1	EDP94923.1	KAOT1_01335	KAOT1_08919	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	COG0642 Signal transduction histidine kinase.	0.653
EDP94827.1	EDP95181.1	KAOT1_01335	KAOT1_06847	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	Sensory box histidine kinase/response regulator.	0.653
EDP94827.1	EDP95497.1	KAOT1_01335	KAOT1_11256	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	COG0642 Signal transduction histidine kinase.	0.526
EDP94827.1	EDP95599.1	KAOT1_01335	KAOT1_22146	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	COG0642 Signal transduction histidine kinase.	0.653
EDP94827.1	EDP95633.1	KAOT1_01335	KAOT1_22316	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	Hybrid sensory kinase; COG0642 Signal transduction histidine kinase.	0.685
EDP94827.1	EDP95634.1	KAOT1_01335	KAOT1_22321	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	Phosphatidylserine decarboxylase; COG0642 Signal transduction histidine kinase.	0.653
EDP94827.1	EDP98159.1	KAOT1_01335	KAOT1_13117	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	COG0642 Signal transduction histidine kinase.	0.519
EDP94827.1	EDP98551.1	KAOT1_01335	KAOT1_15077	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	Sensory box histidine kinase/response regulator.	0.653
EDP94828.1	EDP94826.1	KAOT1_01340	KAOT1_01330	Hypothetical protein.	Hypothetical protein; COG0457 FOG: TPR repeat.	0.417
EDP94828.1	EDP94827.1	KAOT1_01340	KAOT1_01335	Hypothetical protein.	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	0.527
EDP94923.1	EDP94827.1	KAOT1_08919	KAOT1_01335	COG0642 Signal transduction histidine kinase.	Hypothetical protein; COG2771 DNA-binding HTH domain-containing proteins.	0.653
EDP94923.1	EDP95181.1	KAOT1_08919	KAOT1_06847	COG0642 Signal transduction histidine kinase.	Sensory box histidine kinase/response regulator.	0.899
EDP94923.1	EDP95497.1	KAOT1_08919	KAOT1_11256	COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.999
EDP94923.1	EDP95599.1	KAOT1_08919	KAOT1_22146	COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.888
EDP94923.1	EDP95633.1	KAOT1_08919	KAOT1_22316	COG0642 Signal transduction histidine kinase.	Hybrid sensory kinase; COG0642 Signal transduction histidine kinase.	0.945
EDP94923.1	EDP95634.1	KAOT1_08919	KAOT1_22321	COG0642 Signal transduction histidine kinase.	Phosphatidylserine decarboxylase; COG0642 Signal transduction histidine kinase.	0.887

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000105

Histidine biosynthetic process

8 of 11

3.05

9.85

2.52e-19

GO:0008652

Cellular amino acid biosynthetic process

9 of 173

1.91

4.76

9.44e-14

GO:1901564

Organonitrogen compound metabolic process

10 of 2647

0.77

0.72

2.14e-05

GO:0006807

Nitrogen compound metabolic process

11 of 3850

0.65

0.59

2.14e-05

GO:0044238

Primary metabolic process

11 of 4809

0.55

0.47

0.00018

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004400

Histidinol-phosphate transaminase activity

2 of 2

3.19

1.34

0.0038

GO:0003949

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity

2 of 4

2.89

1.29

0.0047

GO:0003824

Catalytic activity

11 of 6088

0.45

0.34

0.0065

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13727

Histidine metabolic process, and AAA domain

10 of 15

3.02

13.0

7.29e-26

CL:13693

Histidine metabolic process, and Aromatic amino acid family biosynthetic process

11 of 32

2.73

12.44

1.50e-26

CL:13731

Histidine metabolic process

8 of 10

3.1

10.41

2.38e-20

CL:13735

Histidine metabolic process

5 of 5

3.19

6.22

3.83e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00340

Histidine metabolism

9 of 51

2.44

8.44

3.55e-19

map01230

Biosynthesis of amino acids

10 of 355

1.64

3.8

1.41e-14

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

3 of 43

2.04

2.01

9.06e-05

map01110

Biosynthesis of secondary metabolites

10 of 1338

1.07

1.39

4.62e-09

map00360

Phenylalanine metabolism

2 of 74

1.62

0.78

0.0267

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0368

Histidine biosynthesis

2 of 4

2.89

1.74

0.00070

KW-0028

Amino-acid biosynthesis

3 of 37

2.1

1.71

0.00048

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011060

Ribulose-phosphate binding barrel

2 of 7

2.65

0.76

0.0430

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