EDP96196.1 protein (Kordia algicida) - STRING interaction network

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Predicted Interactions

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EDP96196.1

COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (742 aa)

Predicted Functional Partners:

EDP95995.1

0.971

EDP95614.1

0.942

mdh

0.919

EDP96667.1

0.917

EDP96110.1

0.886

EDP97280.1

0.884

EDP96650.1

0.865

EDP96666.1

0.864

argH

0.863

EDP97823.1

0.863

Your Current Organism:

Kordia algicida

NCBI taxonomy Id: 391587
Other names: K. algicida OT-1, Kordia algicida NBRC 10036, Kordia algicida OT-1, Kordia algicida str. OT-1, Kordia algicida strain OT-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDP95614.1	EDP96196.1	KAOT1_22221	KAOT1_08503	COG0436 Aspartate/tyrosine/aromatic aminotransferase.	COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family.	0.942
EDP95614.1	EDP96650.1	KAOT1_22221	KAOT1_15843	COG0436 Aspartate/tyrosine/aromatic aminotransferase.	COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.863
EDP95614.1	EDP96666.1	KAOT1_22221	KAOT1_15923	COG0436 Aspartate/tyrosine/aromatic aminotransferase.	Glutamate synthase, small subunit; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases.	0.864
EDP95614.1	EDP96667.1	KAOT1_22221	KAOT1_15928	COG0436 Aspartate/tyrosine/aromatic aminotransferase.	COG0067 Glutamate synthase domain 1.	0.918
EDP95614.1	EDP97823.1	KAOT1_22221	KAOT1_21712	COG0436 Aspartate/tyrosine/aromatic aminotransferase.	COG0436 Aspartate/tyrosine/aromatic aminotransferase.	0.884
EDP95614.1	mdh	KAOT1_22221	KAOT1_10711	COG0436 Aspartate/tyrosine/aromatic aminotransferase.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.886
EDP95995.1	EDP96196.1	KAOT1_07498	KAOT1_08503	Aconitate hydratase; COG1048 Aconitase A.	COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family.	0.971
EDP95995.1	EDP96667.1	KAOT1_07498	KAOT1_15928	Aconitate hydratase; COG1048 Aconitase A.	COG0067 Glutamate synthase domain 1.	0.536
EDP95995.1	EDP97280.1	KAOT1_07498	KAOT1_18997	Aconitate hydratase; COG1048 Aconitase A.	COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes.	0.536
EDP95995.1	mdh	KAOT1_07498	KAOT1_10711	Aconitate hydratase; COG1048 Aconitase A.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.504
EDP96110.1	EDP96196.1	KAOT1_08073	KAOT1_08503	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family.	0.886
EDP96110.1	EDP96667.1	KAOT1_08073	KAOT1_15928	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	COG0067 Glutamate synthase domain 1.	0.470
EDP96110.1	EDP97280.1	KAOT1_08073	KAOT1_18997	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes.	0.891
EDP96110.1	argH	KAOT1_08073	KAOT1_02392	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	COG0165 Argininosuccinate lyase.	0.886
EDP96110.1	mdh	KAOT1_08073	KAOT1_10711	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.895
EDP96196.1	EDP95614.1	KAOT1_08503	KAOT1_22221	COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family.	COG0436 Aspartate/tyrosine/aromatic aminotransferase.	0.942
EDP96196.1	EDP95995.1	KAOT1_08503	KAOT1_07498	COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family.	Aconitate hydratase; COG1048 Aconitase A.	0.971
EDP96196.1	EDP96110.1	KAOT1_08503	KAOT1_08073	COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.886
EDP96196.1	EDP96650.1	KAOT1_08503	KAOT1_15843	COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family.	COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.865
EDP96196.1	EDP96666.1	KAOT1_08503	KAOT1_15923	COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family.	Glutamate synthase, small subunit; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases.	0.864

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Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.846

expected number of edges:

14

PPI enrichment p-value:

0.000109

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045471

Response to ethanol

4 of 5

2.95

3.71

1.54e-07

GO:0006636

Unsaturated fatty acid biosynthetic process

4 of 6

2.87

3.69

1.54e-07

GO:0000001

Mitochondrion inheritance

4 of 11

2.61

3.39

4.16e-07

GO:0006366

Transcription by RNA polymerase II

5 of 89

1.79

2.34

4.13e-06

GO:0022900

Electron transport chain

4 of 61

1.86

2.02

4.65e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004768

stearoyl-CoA 9-desaturase activity

4 of 4

3.04

4.06

3.75e-08

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 26

2.11

1.62

0.00074

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

5 of 14

2.6

4.54

1.86e-09

GO:0030176

Integral component of endoplasmic reticulum membrane

4 of 60

1.87

2.13

2.48e-05

GO:0005736

RNA polymerase I complex

2 of 13

2.23

1.31

0.0035

GO:0005666

RNA polymerase III complex

2 of 18

2.09

1.18

0.0057

GO:0070013

Intracellular organelle lumen

6 of 852

0.89

0.7

0.0023

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11674

Mixed, incl. Fatty acid metabolism, and Acyl-CoA desaturase

4 of 12

2.57

3.15

1.17e-06

CL:11677

Fatty acid metabolism, and Acyl-CoA desaturase

3 of 7

2.68

2.5

2.36e-05

CL:1652

RNA polymerase II, core complex, and Cdc73/Paf1 complex

3 of 15

2.35

2.16

8.01e-05

CL:1626

Mixed, incl. RNA Polymerase II Pre-transcription Events, and RNA Polymerase III Transcription

5 of 153

1.56

1.76

3.84e-05

CL:1899

tRNA transcription, and RNA polymerase I complex

2 of 5

2.65

1.51

0.0017

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

5 of 43

2.11

3.43

5.12e-08

map01040

Biosynthesis of unsaturated fatty acids

5 of 64

1.94

3.01

1.67e-07

map01212

Fatty acid metabolism

5 of 92

1.78

2.59

6.29e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9018519

Estrogen-dependent gene expression

5 of 33

2.22

3.45

9.46e-08

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

5 of 34

2.21

3.43

9.46e-08

MAP-72086

mRNA Capping

5 of 36

2.19

3.41

9.46e-08

MAP-113418

Formation of the Early Elongation Complex

5 of 37

2.18

3.4

9.46e-08

MAP-6796648

TP53 Regulates Transcription of DNA Repair Genes

5 of 45

2.09

3.3

9.46e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

3 of 76

1.64

0.71

0.0397

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0349

Heme

5 of 130

1.63

1.96

1.56e-05

KW-0275

Fatty acid biosynthesis

2 of 7

2.5

1.53

0.0015

KW-0560

Oxidoreductase

5 of 276

1.3

1.29

0.00020

KW-0249

Electron transport

2 of 16

2.14

1.25

0.0043

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00487

Fatty acid desaturase

2 of 10

2.35

0.72

0.0481

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR018506

Cytochrome b5, heme-binding site

5 of 12

2.66

4.45

3.56e-09

IPR015876

Acyl-CoA desaturase

4 of 4

3.04

4.23

1.76e-08

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

5 of 20

2.44

3.99

1.52e-08

IPR001199

Cytochrome b5-like heme/steroid binding domain

5 of 20

2.44

3.99

1.52e-08

IPR009160

Acyl-CoA desaturase, haem/steroid binding domain-containing

2 of 2

3.04

1.44

0.0025

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

5 of 21

2.42

4.23

4.26e-09

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