EDP95523.1 protein (Kordia algicida) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

EDP95523.1

LigB lipoprotein. (439 aa)

Predicted Functional Partners:

EDP95522.1

0.867

EDP95521.1

0.860

EDP97826.1

0.855

EDP97929.1

0.700

EDP96726.1

0.639

EDP95357.1

0.560

EDP95961.1

0.535

EDP95545.1

0.517

EDP95358.1

0.514

EDP95952.1

0.498

Your Current Organism:

Kordia algicida

NCBI taxonomy Id: 391587
Other names: K. algicida OT-1, Kordia algicida NBRC 10036, Kordia algicida OT-1, Kordia algicida str. OT-1, Kordia algicida strain OT-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDP95357.1	EDP95358.1	KAOT1_09801	KAOT1_09806	Fibronectin, type III.	Hypothetical protein; COG1858 Cytochrome c peroxidase.	0.451
EDP95357.1	EDP95521.1	KAOT1_09801	KAOT1_21756	Fibronectin, type III.	Hypothetical protein.	0.509
EDP95357.1	EDP95523.1	KAOT1_09801	KAOT1_21766	Fibronectin, type III.	LigB lipoprotein.	0.560
EDP95357.1	EDP95952.1	KAOT1_09801	KAOT1_07283	Fibronectin, type III.	Hypothetical protein; COG0606 Predicted ATPase with chaperone activity.	0.568
EDP95357.1	EDP96726.1	KAOT1_09801	KAOT1_16223	Fibronectin, type III.	Hypothetical protein.	0.487
EDP95357.1	EDP97826.1	KAOT1_09801	KAOT1_21727	Fibronectin, type III.	COG1629 Outer membrane receptor proteins, mostly Fe transport.	0.484
EDP95358.1	EDP95357.1	KAOT1_09806	KAOT1_09801	Hypothetical protein; COG1858 Cytochrome c peroxidase.	Fibronectin, type III.	0.451
EDP95358.1	EDP95521.1	KAOT1_09806	KAOT1_21756	Hypothetical protein; COG1858 Cytochrome c peroxidase.	Hypothetical protein.	0.452
EDP95358.1	EDP95523.1	KAOT1_09806	KAOT1_21766	Hypothetical protein; COG1858 Cytochrome c peroxidase.	LigB lipoprotein.	0.514
EDP95358.1	EDP95952.1	KAOT1_09806	KAOT1_07283	Hypothetical protein; COG1858 Cytochrome c peroxidase.	Hypothetical protein; COG0606 Predicted ATPase with chaperone activity.	0.588
EDP95358.1	EDP96726.1	KAOT1_09806	KAOT1_16223	Hypothetical protein; COG1858 Cytochrome c peroxidase.	Hypothetical protein.	0.469
EDP95358.1	EDP97826.1	KAOT1_09806	KAOT1_21727	Hypothetical protein; COG1858 Cytochrome c peroxidase.	COG1629 Outer membrane receptor proteins, mostly Fe transport.	0.433
EDP95358.1	EDP97929.1	KAOT1_09806	KAOT1_11967	Hypothetical protein; COG1858 Cytochrome c peroxidase.	Lysyl endopeptidase precursor; COG5651 PPE-repeat proteins.	0.403
EDP95521.1	EDP95357.1	KAOT1_21756	KAOT1_09801	Hypothetical protein.	Fibronectin, type III.	0.509
EDP95521.1	EDP95358.1	KAOT1_21756	KAOT1_09806	Hypothetical protein.	Hypothetical protein; COG1858 Cytochrome c peroxidase.	0.452
EDP95521.1	EDP95522.1	KAOT1_21756	KAOT1_21761	Hypothetical protein.	Hypothetical protein; COG0526 Thiol-disulfide isomerase and thioredoxins.	0.915
EDP95521.1	EDP95523.1	KAOT1_21756	KAOT1_21766	Hypothetical protein.	LigB lipoprotein.	0.860
EDP95521.1	EDP95545.1	KAOT1_21756	KAOT1_21876	Hypothetical protein.	Fibronectin type III domain protein.	0.436
EDP95521.1	EDP95952.1	KAOT1_21756	KAOT1_07283	Hypothetical protein.	Hypothetical protein; COG0606 Predicted ATPase with chaperone activity.	0.506
EDP95521.1	EDP95961.1	KAOT1_21756	KAOT1_07328	Hypothetical protein.	Hypothetical protein.	0.439

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.716

expected number of edges:

10

PPI enrichment p-value:

7.08e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

3 of 14

1.73

1.19

0.0035

GO:0006412

Translation

6 of 91

1.21

1.08

0.00066

GO:0019538

Protein metabolic process

7 of 249

0.84

0.67

0.0019

GO:0044249

Cellular biosynthetic process

8 of 458

0.64

0.46

0.0060

GO:1901576

Organic substance biosynthetic process

8 of 477

0.62

0.44

0.0075

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

6 of 49

1.48

1.8

1.11e-05

GO:0019843

rRNA binding

5 of 39

1.5

1.63

6.39e-05

GO:0000036

Acyl carrier activity

2 of 2

2.39

1.11

0.0092

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

6 of 52

1.46

1.86

4.25e-06

GO:0015934

Large ribosomal subunit

2 of 6

1.92

1.04

0.0098

GO:0005622

Intracellular anatomical structure

9 of 907

0.39

0.28

0.0269

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:186

rRNA-binding

6 of 15

2.0

3.4

2.30e-08

CL:187

Mixed, incl. Large ribosomal subunit, and tRNA-binding

5 of 9

2.14

3.3

1.30e-07

CL:153

Peptide metabolic process, and Proton channel activity

7 of 149

1.07

1.12

2.31e-05

CL:1783

Mixed, incl. Steroid biosynthesis, and ANL, N-terminal domain

2 of 7

1.85

0.97

0.0130

CL:1684

Mixed, incl. Oxidative phosphorylation, and Terpenoid metabolic process

4 of 62

1.2

0.95

0.0025

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

6 of 49

1.48

1.95

2.36e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

5 of 34

1.56

1.74

4.64e-05

GOCC:0015934

Large ribosomal subunit

3 of 6

2.09

1.71

0.00047

GOCC:0022625

Cytosolic large ribosomal subunit

2 of 3

2.22

1.31

0.0035

GOCC:0043232

Intracellular non-membrane-bounded organelle

6 of 131

1.06

0.95

0.00047

GOCC:0043229

Intracellular organelle

7 of 274

0.8

0.66

0.0010

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

6 of 51

1.47

1.85

5.24e-06

KW-0687

Ribonucleoprotein

6 of 51

1.47

1.85

5.24e-06

KW-0699

rRNA-binding

5 of 38

1.51

1.77

2.14e-05

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