node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEB83808.1 | hemA | RGAI101_957 | RGAI101_440 | Non-ribosomal peptide synthetase, putative; [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | 5-aminolevulinic acid synthase; [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | 0.835 |
EEB83808.1 | hemB | RGAI101_957 | RGAI101_1484 | Non-ribosomal peptide synthetase, putative; [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | [H] COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.714 |
EEB83808.1 | kbl | RGAI101_957 | RGAI101_2602 | Non-ribosomal peptide synthetase, putative; [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.835 |
EEB83808.1 | mfd | RGAI101_957 | RGAI101_1573 | Non-ribosomal peptide synthetase, putative; [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.609 |
cysG_1 | cysG_2 | RGAI101_2178 | RGAI101_1644 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | 0.999 |
cysG_1 | cysG_3 | RGAI101_2178 | RGAI101_978 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.967 |
cysG_1 | hemB | RGAI101_2178 | RGAI101_1484 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | [H] COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.929 |
cysG_1 | hemC | RGAI101_2178 | RGAI101_3606 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.945 |
cysG_1 | hemD | RGAI101_2178 | RGAI101_1378 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.858 |
cysG_1 | hemE | RGAI101_2178 | RGAI101_1370 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.841 |
cysG_2 | cysG_1 | RGAI101_1644 | RGAI101_2178 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | 0.999 |
cysG_2 | cysG_3 | RGAI101_1644 | RGAI101_978 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.980 |
cysG_2 | hemB | RGAI101_1644 | RGAI101_1484 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | [H] COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.968 |
cysG_2 | hemC | RGAI101_1644 | RGAI101_3606 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.973 |
cysG_2 | hemD | RGAI101_1644 | RGAI101_1378 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.878 |
cysG_2 | hemE | RGAI101_1644 | RGAI101_1370 | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.863 |
cysG_3 | cysG_1 | RGAI101_978 | RGAI101_2178 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | 0.967 |
cysG_3 | cysG_2 | RGAI101_978 | RGAI101_1644 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Siroheme synthase; [H] COG2875 Precorrin-4 methylase; overlaps another CDS with the same product name. | 0.980 |
cysG_3 | hemB | RGAI101_978 | RGAI101_1484 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | [H] COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.952 |
cysG_3 | hemC | RGAI101_978 | RGAI101_3606 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.980 |