| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEB83755.1 | EEB86109.1 | RGAI101_904 | RGAI101_3265 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | 0.991 |
| EEB83755.1 | clpP | RGAI101_904 | RGAI101_434 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.467 |
| EEB83755.1 | dnaJ | RGAI101_904 | RGAI101_2717 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.985 |
| EEB83755.1 | groL | RGAI101_904 | RGAI101_2120 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.991 |
| EEB83755.1 | groS | RGAI101_904 | RGAI101_2856 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.968 |
| EEB83755.1 | grpE_1 | RGAI101_904 | RGAI101_2525 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.984 |
| EEB83755.1 | grpE_2 | RGAI101_904 | RGAI101_4217 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.984 |
| EEB83755.1 | hslU | RGAI101_904 | RGAI101_1937 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.551 |
| EEB83755.1 | hslV | RGAI101_904 | RGAI101_1531 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.482 |
| EEB86109.1 | EEB83755.1 | RGAI101_3265 | RGAI101_904 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | 0.991 |
| EEB86109.1 | clpP | RGAI101_3265 | RGAI101_434 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.611 |
| EEB86109.1 | dnaJ | RGAI101_3265 | RGAI101_2717 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.986 |
| EEB86109.1 | dnaK | RGAI101_3265 | RGAI101_323 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |
| EEB86109.1 | groL | RGAI101_3265 | RGAI101_2120 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.994 |
| EEB86109.1 | groS | RGAI101_3265 | RGAI101_2856 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.917 |
| EEB86109.1 | grpE_1 | RGAI101_3265 | RGAI101_2525 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.829 |
| EEB86109.1 | grpE_2 | RGAI101_3265 | RGAI101_4217 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.829 |
| EEB86109.1 | hslU | RGAI101_3265 | RGAI101_1937 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.902 |
| EEB86109.1 | hslV | RGAI101_3265 | RGAI101_1531 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.908 |
| clpP | EEB83755.1 | RGAI101_434 | RGAI101_904 | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | 0.467 |
