| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEB83755.1 | EEB86109.1 | RGAI101_904 | RGAI101_3265 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | 0.991 |
| EEB83755.1 | dnaJ | RGAI101_904 | RGAI101_2717 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.985 |
| EEB83755.1 | groL | RGAI101_904 | RGAI101_2120 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.991 |
| EEB83755.1 | grpE_1 | RGAI101_904 | RGAI101_2525 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.984 |
| EEB83755.1 | hslU | RGAI101_904 | RGAI101_1937 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.551 |
| EEB83755.1 | hslV | RGAI101_904 | RGAI101_1531 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.482 |
| EEB83755.1 | lon | RGAI101_904 | RGAI101_3045 | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.572 |
| EEB84510.1 | lon | RGAI101_1660 | RGAI101_3045 | Conserved hypothetical protein. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.719 |
| EEB86109.1 | EEB83755.1 | RGAI101_3265 | RGAI101_904 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Molecular chaperone, DnaK; [O] COG0443 Molecular chaperone. | 0.991 |
| EEB86109.1 | clpX | RGAI101_3265 | RGAI101_3028 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.465 |
| EEB86109.1 | dnaJ | RGAI101_3265 | RGAI101_2717 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.986 |
| EEB86109.1 | dnaK | RGAI101_3265 | RGAI101_323 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |
| EEB86109.1 | groL | RGAI101_3265 | RGAI101_2120 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.994 |
| EEB86109.1 | grpE_1 | RGAI101_3265 | RGAI101_2525 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.829 |
| EEB86109.1 | hslU | RGAI101_3265 | RGAI101_1937 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.902 |
| EEB86109.1 | hslV | RGAI101_3265 | RGAI101_1531 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.908 |
| EEB86109.1 | lon | RGAI101_3265 | RGAI101_3045 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.721 |
| clpX | EEB86109.1 | RGAI101_3028 | RGAI101_3265 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | 0.465 |
| clpX | dnaJ | RGAI101_3028 | RGAI101_2717 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.447 |
| clpX | dnaK | RGAI101_3028 | RGAI101_323 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.555 |
