STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hemA5-aminolevulinic acid synthase; [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. (407 aa)    
Predicted Functional Partners:
EEB83808.1
Non-ribosomal peptide synthetase, putative; [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
  
 0.898
tdh
L-threonine 3-dehydrogenase; [C] COG1062 Zn-dependent alcohol dehydrogenases, class III.
 
 
 0.884
hemB
[H] COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
    
 0.862
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
 
 0.850
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
  
 0.775
EEB84343.1
Sarcosine oxidase, alpha subunit family; [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family.
  
 
 0.762
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
  
 
0.741
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.737
EEB84114.1
Sarcosine oxidase, alpha subunit family; [E] COG0404 Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family.
  
 
 0.735
ltaE
Low-specificity L-threonine aldolase; [E] COG2008 Threonine aldolase.
   
 
 0.702
Your Current Organism:
Roseobacter sp. GAI101
NCBI taxonomy Id: 391589
Other names: R. sp. GAI101
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.