Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cysDO-acetylhomoserine (thiol)-lyase; [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (430 aa)    
Predicted Functional Partners:
metA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
 
 
 0.970
metX
[E] COG2021 Homoserine acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family.
 
 
 0.953
EEB86150.1
CoA-binding domain protein; [E] COG0346 Lactoylglutathione lyase and related lyases.
   
  0.952
EEB84862.1
5-methyltetrahydrofolate--homocysteine S-methyltransferase; [E] COG1410 Methionine synthase I, cobalamin-binding domain.
  
 
 0.833
hom
[E] COG0460 Homoserine dehydrogenase.
  
 
 0.832
cysB
Cysteine synthase; [E] COG1171 Threonine dehydratase.
 
 
 0.815
EEB82977.1
Aminotransferase, class I and II; [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase.
    
 0.811
EEB83523.1
[E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases.
 
 
0.795
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
 
 0.786
metZ
O-succinylhomoserine sulfhydrylase; [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase.
 
 
0.779
Your Current Organism:
Roseobacter sp. GAI101
NCBI taxonomy Id: 391589
Other names: R. sp. GAI101
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