STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDM24029.1COG0374 Ni,Fe-hydrogenase I large subunit. (386 aa)    
Predicted Functional Partners:
EDM24028.1
NADH ubiquinone oxidoreductase, 20 kDa subunit; COG1740 Ni,Fe-hydrogenase I small subunit.
 
 
 0.989
cybH
COG1969 Ni,Fe-hydrogenase I cytochrome b subunit.
 
 
 0.961
EDM24030.1
COG1740 Ni,Fe-hydrogenase I small subunit.
 
 
 0.932
EDM23778.1
COG1740 Ni,Fe-hydrogenase I small subunit.
 
 
 0.899
hypA-2
Hydrogenase expression/synthesis, HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.863
EDM24027.1
Transcriptional regulator, TetR family protein; COG1309 Transcriptional regulator.
 
     0.846
hypD
Hydrogenase formation HypD protein; COG0409 Hydrogenase maturation factor; Belongs to the HypD family.
 
 
 0.813
EDM24053.1
Hydrogenase isoenzyme formation protein HypC; COG0298 Hydrogenase maturation factor.
 
 
 0.776
hypE
Hydrogenase expression/formation protein HypE; COG0309 Hydrogenase maturation factor.
 
   
 0.774
hypF
Transcriptional regulatory protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
 
 
 0.767
Your Current Organism:
Caminibacter mediatlanticus
NCBI taxonomy Id: 391592
Other names: C. mediatlanticus TB-2, Caminibacter mediatlanticus DSM 16658, Caminibacter mediatlanticus TB-2, Caminibacter mediatlanticus str. TB-2, Caminibacter mediatlanticus strain TB-2
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.