node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEI94924.1 | hisA | RLO149_c029680 | RLO149_c026210 | Putative histidinol-phosphate aminotransferase. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | 0.814 |
AEI94924.1 | hisB | RLO149_c029680 | RLO149_c026170 | Putative histidinol-phosphate aminotransferase. | Imidazoleglycerol-phosphate dehydratase HisB. | 0.989 |
AEI94924.1 | hisE | RLO149_c029680 | RLO149_c026230 | Putative histidinol-phosphate aminotransferase. | phosphoribosyl-ATP pyrophosphatase HisE. | 0.735 |
AEI94924.1 | hisF | RLO149_c029680 | RLO149_c026220 | Putative histidinol-phosphate aminotransferase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.838 |
AEI94924.1 | hisG | RLO149_c029680 | RLO149_c004090 | Putative histidinol-phosphate aminotransferase. | ATP-phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.848 |
AEI94924.1 | hisH | RLO149_c029680 | RLO149_c026180 | Putative histidinol-phosphate aminotransferase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.880 |
AEI94924.1 | hisL | RLO149_c029680 | RLO149_c019520 | Putative histidinol-phosphate aminotransferase. | phosphoribosyl-AMP cyclohydrolase HisL; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.864 |
AEI94924.1 | hisZ | RLO149_c029680 | RLO149_c004080 | Putative histidinol-phosphate aminotransferase. | ATP phosphoribosyltransferase regulatory subunit HisZ. | 0.718 |
hisA | AEI94924.1 | RLO149_c026210 | RLO149_c029680 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | Putative histidinol-phosphate aminotransferase. | 0.814 |
hisA | hisB | RLO149_c026210 | RLO149_c026170 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | Imidazoleglycerol-phosphate dehydratase HisB. | 0.986 |
hisA | hisE | RLO149_c026210 | RLO149_c026230 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | phosphoribosyl-ATP pyrophosphatase HisE. | 0.993 |
hisA | hisF | RLO149_c026210 | RLO149_c026220 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | RLO149_c026210 | RLO149_c004090 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | ATP-phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.941 |
hisA | hisH | RLO149_c026210 | RLO149_c026180 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
hisA | hisL | RLO149_c026210 | RLO149_c019520 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | phosphoribosyl-AMP cyclohydrolase HisL; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisS | RLO149_c026210 | RLO149_c004070 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | histidyl-tRNA synthetase HisS. | 0.457 |
hisA | hisZ | RLO149_c026210 | RLO149_c004080 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | ATP phosphoribosyltransferase regulatory subunit HisZ. | 0.908 |
hisB | AEI94924.1 | RLO149_c026170 | RLO149_c029680 | Imidazoleglycerol-phosphate dehydratase HisB. | Putative histidinol-phosphate aminotransferase. | 0.989 |
hisB | hisA | RLO149_c026170 | RLO149_c026210 | Imidazoleglycerol-phosphate dehydratase HisB. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase HisA. | 0.986 |
hisB | hisE | RLO149_c026170 | RLO149_c026230 | Imidazoleglycerol-phosphate dehydratase HisB. | phosphoribosyl-ATP pyrophosphatase HisE. | 0.978 |