node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDM34865.1 | dut | PBAL39_03175 | PBAL39_04873 | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.929 |
EDM34865.1 | tdk | PBAL39_03175 | PBAL39_07180 | 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | COG1435 Thymidine kinase. | 0.926 |
EDM35764.1 | EDM35809.1 | PBAL39_06281 | PBAL39_06506 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Cytidine/deoxycytidylate deaminase (dCMP deaminase); COG2131 Deoxycytidylate deaminase. | 0.419 |
EDM35764.1 | dut | PBAL39_06281 | PBAL39_04873 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.926 |
EDM35764.1 | thyA | PBAL39_06281 | PBAL39_13562 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.541 |
EDM35809.1 | EDM35764.1 | PBAL39_06506 | PBAL39_06281 | Cytidine/deoxycytidylate deaminase (dCMP deaminase); COG2131 Deoxycytidylate deaminase. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.419 |
EDM35809.1 | dcd | PBAL39_06506 | PBAL39_09976 | Cytidine/deoxycytidylate deaminase (dCMP deaminase); COG2131 Deoxycytidylate deaminase. | COG0717 Deoxycytidine deaminase. | 0.508 |
EDM35809.1 | dut | PBAL39_06506 | PBAL39_04873 | Cytidine/deoxycytidylate deaminase (dCMP deaminase); COG2131 Deoxycytidylate deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.953 |
EDM35809.1 | tdk | PBAL39_06506 | PBAL39_07180 | Cytidine/deoxycytidylate deaminase (dCMP deaminase); COG2131 Deoxycytidylate deaminase. | COG1435 Thymidine kinase. | 0.946 |
EDM35809.1 | thyA | PBAL39_06506 | PBAL39_13562 | Cytidine/deoxycytidylate deaminase (dCMP deaminase); COG2131 Deoxycytidylate deaminase. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.951 |
EDM37101.1 | EDM37102.1 | PBAL39_04863 | PBAL39_04868 | Hypothetical protein. | TPR-repeat-containing protein; COG0457 FOG: TPR repeat. | 0.893 |
EDM37101.1 | dut | PBAL39_04863 | PBAL39_04873 | Hypothetical protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.876 |
EDM37102.1 | EDM37101.1 | PBAL39_04868 | PBAL39_04863 | TPR-repeat-containing protein; COG0457 FOG: TPR repeat. | Hypothetical protein. | 0.893 |
EDM37102.1 | dut | PBAL39_04868 | PBAL39_04873 | TPR-repeat-containing protein; COG0457 FOG: TPR repeat. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.881 |
EDM38723.1 | dut | PBAL39_21660 | PBAL39_04873 | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.800 |
EDM38723.1 | thyA | PBAL39_21660 | PBAL39_13562 | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.805 |
dcd | EDM35809.1 | PBAL39_09976 | PBAL39_06506 | COG0717 Deoxycytidine deaminase. | Cytidine/deoxycytidylate deaminase (dCMP deaminase); COG2131 Deoxycytidylate deaminase. | 0.508 |
dcd | dut | PBAL39_09976 | PBAL39_04873 | COG0717 Deoxycytidine deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.941 |
dcd | ndk | PBAL39_09976 | PBAL39_08736 | COG0717 Deoxycytidine deaminase. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.943 |
dcd | tdk | PBAL39_09976 | PBAL39_07180 | COG0717 Deoxycytidine deaminase. | COG1435 Thymidine kinase. | 0.619 |