node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDM35280.1 | EDM36494.1 | PBAL39_13647 | PBAL39_12337 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | COG0134 Indole-3-glycerol phosphate synthase. | 0.535 |
EDM35280.1 | EDM36495.1 | PBAL39_13647 | PBAL39_12342 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | COG0134 Indole-3-glycerol phosphate synthase. | 0.535 |
EDM35280.1 | glyA | PBAL39_13647 | PBAL39_04923 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
EDM35280.1 | ilvA | PBAL39_13647 | PBAL39_23302 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.950 |
EDM35280.1 | trpA | PBAL39_13647 | PBAL39_19759 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.938 |
EDM35280.1 | trpB | PBAL39_13647 | PBAL39_19764 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.927 |
EDM35280.1 | trpF | PBAL39_13647 | PBAL39_19769 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | COG0135 Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.729 |
EDM36492.1 | EDM36493.1 | PBAL39_12327 | PBAL39_12332 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | COG0512 Anthranilate/para-aminobenzoate synthases component II. | 0.999 |
EDM36492.1 | EDM36494.1 | PBAL39_12327 | PBAL39_12337 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | COG0134 Indole-3-glycerol phosphate synthase. | 0.991 |
EDM36492.1 | EDM36495.1 | PBAL39_12327 | PBAL39_12342 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | COG0134 Indole-3-glycerol phosphate synthase. | 0.994 |
EDM36492.1 | trpA | PBAL39_12327 | PBAL39_19759 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.932 |
EDM36492.1 | trpB | PBAL39_12327 | PBAL39_19764 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.957 |
EDM36492.1 | trpD | PBAL39_12327 | PBAL39_19774 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
EDM36492.1 | trpF | PBAL39_12327 | PBAL39_19769 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | COG0135 Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.972 |
EDM36493.1 | EDM36492.1 | PBAL39_12332 | PBAL39_12327 | COG0512 Anthranilate/para-aminobenzoate synthases component II. | COG0147 Anthranilate/para-aminobenzoate synthases component I. | 0.999 |
EDM36493.1 | EDM36494.1 | PBAL39_12332 | PBAL39_12337 | COG0512 Anthranilate/para-aminobenzoate synthases component II. | COG0134 Indole-3-glycerol phosphate synthase. | 0.977 |
EDM36493.1 | EDM36495.1 | PBAL39_12332 | PBAL39_12342 | COG0512 Anthranilate/para-aminobenzoate synthases component II. | COG0134 Indole-3-glycerol phosphate synthase. | 0.988 |
EDM36493.1 | trpA | PBAL39_12332 | PBAL39_19759 | COG0512 Anthranilate/para-aminobenzoate synthases component II. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.976 |
EDM36493.1 | trpB | PBAL39_12332 | PBAL39_19764 | COG0512 Anthranilate/para-aminobenzoate synthases component II. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.985 |
EDM36493.1 | trpD | PBAL39_12332 | PBAL39_19774 | COG0512 Anthranilate/para-aminobenzoate synthases component II. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |