node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDM35280.1 | EDM35978.1 | PBAL39_13647 | PBAL39_23262 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.694 |
EDM35280.1 | EDM37063.1 | PBAL39_13647 | PBAL39_04673 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | COG0498 Threonine synthase. | 0.433 |
EDM35280.1 | EDM37449.1 | PBAL39_13647 | PBAL39_09906 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.941 |
EDM35280.1 | glyA | PBAL39_13647 | PBAL39_04923 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
EDM35280.1 | ilvA | PBAL39_13647 | PBAL39_23302 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.950 |
EDM35280.1 | trpB | PBAL39_13647 | PBAL39_19764 | Cystathionine beta-synthase; COG0031 Cysteine synthase. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.927 |
EDM35977.1 | EDM35978.1 | PBAL39_23257 | PBAL39_23262 | Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.999 |
EDM35977.1 | EDM37063.1 | PBAL39_23257 | PBAL39_04673 | Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0498 Threonine synthase. | 0.520 |
EDM35977.1 | EDM37449.1 | PBAL39_23257 | PBAL39_09906 | Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.547 |
EDM35977.1 | EDM37642.1 | PBAL39_23257 | PBAL39_14494 | Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Transketolase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.771 |
EDM35977.1 | ilvA | PBAL39_23257 | PBAL39_23302 | Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.979 |
EDM35977.1 | leuB | PBAL39_23257 | PBAL39_23292 | Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.992 |
EDM35977.1 | leuD | PBAL39_23257 | PBAL39_23282 | Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.940 |
EDM35978.1 | EDM35280.1 | PBAL39_23262 | PBAL39_13647 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Cystathionine beta-synthase; COG0031 Cysteine synthase. | 0.694 |
EDM35978.1 | EDM35977.1 | PBAL39_23262 | PBAL39_23257 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.999 |
EDM35978.1 | EDM37063.1 | PBAL39_23262 | PBAL39_04673 | COG0440 Acetolactate synthase, small (regulatory) subunit. | COG0498 Threonine synthase. | 0.687 |
EDM35978.1 | EDM37449.1 | PBAL39_23262 | PBAL39_09906 | COG0440 Acetolactate synthase, small (regulatory) subunit. | COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.659 |
EDM35978.1 | EDM37642.1 | PBAL39_23262 | PBAL39_14494 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Transketolase; COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. | 0.722 |
EDM35978.1 | ilvA | PBAL39_23262 | PBAL39_23302 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.990 |
EDM35978.1 | leuB | PBAL39_23262 | PBAL39_23292 | COG0440 Acetolactate synthase, small (regulatory) subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.995 |