EDM83968.1 protein (Limnobacter sp. MED105) - STRING interaction network

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Known Interactions

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Predicted Interactions

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gene co-occurrence

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protein homology

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Score

EDM83968.1

Histidine Kinase; COG5278 Predicted periplasmic ligand-binding sensor domain. (424 aa)

Predicted Functional Partners:

EDM82659.1

0.864

EDM83969.1

0.864

EDM84924.1

0.863

EDM84926.1

0.863

EDM84976.1

0.863

EDM83401.1

0.863

EDM83263.1

0.863

EDM82945.1

0.863

EDM82809.1

0.862

EDM84231.1

0.860

Your Current Organism:

Limnobacter sp. MED105

NCBI taxonomy Id: 391597
Other names: L. sp. MED105

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDM82659.1	EDM82809.1	LMED105_11345	LMED105_16148	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.771
EDM82659.1	EDM83263.1	LMED105_11345	LMED105_10130	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.420
EDM82659.1	EDM83968.1	LMED105_11345	LMED105_13368	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Histidine Kinase; COG5278 Predicted periplasmic ligand-binding sensor domain.	0.864
EDM82659.1	EDM84976.1	LMED105_11345	LMED105_05487	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.504
EDM82809.1	EDM82659.1	LMED105_16148	LMED105_11345	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.771
EDM82809.1	EDM82945.1	LMED105_16148	LMED105_10715	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.771
EDM82809.1	EDM83263.1	LMED105_16148	LMED105_10130	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.774
EDM82809.1	EDM83401.1	LMED105_16148	LMED105_08902	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.770
EDM82809.1	EDM83968.1	LMED105_16148	LMED105_13368	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Histidine Kinase; COG5278 Predicted periplasmic ligand-binding sensor domain.	0.862
EDM82809.1	EDM83969.1	LMED105_16148	LMED105_13373	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two Component Transcriptional Regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.773
EDM82809.1	EDM84231.1	LMED105_16148	LMED105_01673	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.768
EDM82809.1	EDM84926.1	LMED105_16148	LMED105_05237	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.774
EDM82809.1	EDM84976.1	LMED105_16148	LMED105_05487	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.772
EDM82945.1	EDM82809.1	LMED105_10715	LMED105_16148	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.771
EDM82945.1	EDM83968.1	LMED105_10715	LMED105_13368	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Histidine Kinase; COG5278 Predicted periplasmic ligand-binding sensor domain.	0.863
EDM82945.1	EDM84231.1	LMED105_10715	LMED105_01673	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.773
EDM83263.1	EDM82659.1	LMED105_10130	LMED105_11345	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.420
EDM83263.1	EDM82809.1	LMED105_10130	LMED105_16148	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.774
EDM83263.1	EDM83401.1	LMED105_10130	LMED105_08902	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Two component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	0.435
EDM83263.1	EDM83968.1	LMED105_10130	LMED105_13368	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.	Histidine Kinase; COG5278 Predicted periplasmic ligand-binding sensor domain.	0.863

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.81

expected number of edges:

12

PPI enrichment p-value:

9.02e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042128

Nitrate assimilation

5 of 6

2.52

4.0

1.98e-08

GO:0043436

Oxoacid metabolic process

7 of 316

0.95

0.81

0.00071

GO:0044281

Small molecule metabolic process

8 of 611

0.72

0.54

0.0030

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008942

Nitrite reductase [NAD(P)H] activity

4 of 5

2.5

3.01

1.95e-06

GO:0050661

NADP binding

4 of 24

1.82

2.0

4.42e-05

GO:0020037

Heme binding

4 of 26

1.79

1.95

5.16e-05

GO:0051536

Iron-sulfur cluster binding

6 of 82

1.46

1.89

3.41e-06

GO:0050660

Flavin adenine dinucleotide binding

3 of 29

1.61

1.14

0.0037

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2600

Nitrate assimilation

6 of 7

2.53

5.25

4.60e-11

CL:2598

Mixed, incl. Nitrate assimilation, and Molybdopterin oxidoreductase

7 of 20

2.14

4.64

4.60e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00910

Nitrogen metabolism

6 of 24

2.0

3.7

3.37e-09

map01120

Microbial metabolism in diverse environments

8 of 262

1.08

1.26

1.62e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0411

Iron-sulfur

5 of 42

1.68

2.06

1.10e-05

KW-0349

Heme

3 of 14

1.93

1.7

0.00035

KW-0004

4Fe-4S

4 of 36

1.65

1.67

0.00014

KW-0560

Oxidoreductase

6 of 196

1.09

1.04

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01077

Nitrite and sulphite reductase 4Fe-4S domain

4 of 4

2.6

3.2

9.69e-07

PF04324

BFD-like [2Fe-2S] binding domain

3 of 3

2.6

2.22

7.60e-05

PF03460

Nitrite/Sulfite reductase ferredoxin-like half domain

3 of 3

2.6

2.22

7.60e-05

PF13738

Pyridine nucleotide-disulphide oxidoreductase

3 of 5

2.38

2.1

0.00011

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