node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBAL3_2109 | BBAL3_247 | BBAL3_2109 | BBAL3_247 | Hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | HAD-superfamily hydrolase, subfamily IB (PSPase-like), putative; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.466 |
BBAL3_2109 | hisA | BBAL3_2109 | BBAL3_1965 | Hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.685 |
BBAL3_2109 | hisB | BBAL3_2109 | BBAL3_2471 | Hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | [E] COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.920 |
BBAL3_2109 | hisC | BBAL3_2109 | BBAL3_1311 | Hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.505 |
BBAL3_2109 | hisD | BBAL3_2109 | BBAL3_3271 | Hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.588 |
BBAL3_2109 | hisF | BBAL3_2109 | BBAL3_2310 | Hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.733 |
BBAL3_2109 | hisH | BBAL3_2109 | BBAL3_3036 | Hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.692 |
BBAL3_2109 | hisI | BBAL3_2109 | BBAL3_1712 | Hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | phosphoribosyl-ATP pyrophosphohydrolase domain protein; [E] COG0139 Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.990 |
BBAL3_247 | BBAL3_2109 | BBAL3_247 | BBAL3_2109 | HAD-superfamily hydrolase, subfamily IB (PSPase-like), putative; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | 0.466 |
BBAL3_247 | hisA | BBAL3_247 | BBAL3_1965 | HAD-superfamily hydrolase, subfamily IB (PSPase-like), putative; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.775 |
BBAL3_247 | hisB | BBAL3_247 | BBAL3_2471 | HAD-superfamily hydrolase, subfamily IB (PSPase-like), putative; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | [E] COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.997 |
BBAL3_247 | hisC | BBAL3_247 | BBAL3_1311 | HAD-superfamily hydrolase, subfamily IB (PSPase-like), putative; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.811 |
BBAL3_247 | hisD | BBAL3_247 | BBAL3_3271 | HAD-superfamily hydrolase, subfamily IB (PSPase-like), putative; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.869 |
BBAL3_247 | hisF | BBAL3_247 | BBAL3_2310 | HAD-superfamily hydrolase, subfamily IB (PSPase-like), putative; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.905 |
BBAL3_247 | hisG | BBAL3_247 | BBAL3_2053 | HAD-superfamily hydrolase, subfamily IB (PSPase-like), putative; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.704 |
BBAL3_247 | hisH | BBAL3_247 | BBAL3_3036 | HAD-superfamily hydrolase, subfamily IB (PSPase-like), putative; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.751 |
BBAL3_247 | hisI | BBAL3_247 | BBAL3_1712 | HAD-superfamily hydrolase, subfamily IB (PSPase-like), putative; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | phosphoribosyl-ATP pyrophosphohydrolase domain protein; [E] COG0139 Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.998 |
BBAL3_2910 | hisA | BBAL3_2910 | BBAL3_1965 | Histidinol-phosphate phosphatase family domain; [E] COG0241 Histidinol phosphatase and related phosphatases. | [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.774 |
BBAL3_2910 | hisB | BBAL3_2910 | BBAL3_2471 | Histidinol-phosphate phosphatase family domain; [E] COG0241 Histidinol phosphatase and related phosphatases. | [E] COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.901 |
BBAL3_2910 | hisC | BBAL3_2910 | BBAL3_1311 | Histidinol-phosphate phosphatase family domain; [E] COG0241 Histidinol phosphatase and related phosphatases. | [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.827 |