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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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filled nodes:
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[Homology]
Score
hisC_1[E] COG0436 Aspartate/tyrosine/aromatic aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (376 aa)    
Predicted Functional Partners:
hisB
[E] COG0131 Imidazoleglycerol-phosphate dehydratase.
 
 0.994
EDY87605.1
[E] COG0287 Prephenate dehydrogenase.
  
 
 0.974
EDY87700.1
P-protein; [E] COG1605 Chorismate mutase.
  
 
 0.974
hisD_1
[E] COG0141 Histidinol dehydrogenase.
 
 0.952
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.935
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
 0.891
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
  
  
 0.885
hisD_2
[E] COG0141 Histidinol dehydrogenase; Belongs to the histidinol dehydrogenase family.
 
 0.851
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase.
  
  
 0.832
dat
D-alanine aminotransferase; [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase.
  
 
  0.821
Your Current Organism:
gamma proteobacterium HTCC5015
NCBI taxonomy Id: 391615
Other names: g. proteobacterium HTCC5015
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