Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gmkGuanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. (217 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
 
 0.965
hpt
Hypoxanthine phosphoribosyltransferase Hpt; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.954
spoT
Guanosine-3', 5'-bis[diphosphate]3'-pyrophosphohydrolase SpoT; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.940
AGI72038.1
Putative YicC-like protein.
  
    0.938
purB
Adenylosuccinate lyase PurB; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
 0.929
ndk
Nucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.929
gpt
Xanthine phosphoribosyltransferase Gpt; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
   
 0.918
AGI72811.1
Glutamine amidotransferase class-I.
  
 
 0.917
surE
5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
  
  
  0.914
AGI70751.1
Putative vitamin B12-dependent ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
     
 0.904
Your Current Organism:
Octadecabacter arcticus
NCBI taxonomy Id: 391616
Other names: O. arcticus 238, Octadecabacter arcticus 238, Octadecabacter arcticus CIP 106732, Octadecabacter arcticus str. 238, Octadecabacter arcticus strain 238
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