AFO90051.1 protein (Phaeobacter inhibens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

AFO90051.1

Hypothetical protein. (161 aa)

Predicted Functional Partners:

AFO92429.1

0.715

AFO92280.1

0.665

AFO90050.1

0.550

AFO90066.1

0.544

AFO91517.1

0.544

AFO91805.1

0.544

AFO90052.1

0.541

AFO90053.1

0.537

AFO90048.1

0.517

AFO90049.1

0.503

Your Current Organism:

Phaeobacter inhibens

NCBI taxonomy Id: 391619
Other names: P. inhibens DSM 17395, Phaeobacter gallaeciensis DSM 17395, Phaeobacter inhibens DSM 17395

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFO90048.1	AFO90049.1	PGA1_c03150	PGA1_c03160	Putative acyl-CoA dehydrogenase.	Metallo-beta-lactamase-like protein.	0.820
AFO90048.1	AFO90050.1	PGA1_c03150	PGA1_c03170	Putative acyl-CoA dehydrogenase.	Hypothetical protein.	0.693
AFO90048.1	AFO90051.1	PGA1_c03150	PGA1_c03180	Putative acyl-CoA dehydrogenase.	Hypothetical protein.	0.517
AFO90049.1	AFO90048.1	PGA1_c03160	PGA1_c03150	Metallo-beta-lactamase-like protein.	Putative acyl-CoA dehydrogenase.	0.820
AFO90049.1	AFO90050.1	PGA1_c03160	PGA1_c03170	Metallo-beta-lactamase-like protein.	Hypothetical protein.	0.811
AFO90049.1	AFO90051.1	PGA1_c03160	PGA1_c03180	Metallo-beta-lactamase-like protein.	Hypothetical protein.	0.503
AFO90049.1	AFO90052.1	PGA1_c03160	PGA1_c03190	Metallo-beta-lactamase-like protein.	Hypothetical protein.	0.516
AFO90049.1	AFO90053.1	PGA1_c03160	PGA1_c03200	Metallo-beta-lactamase-like protein.	Hypothetical protein.	0.623
AFO90050.1	AFO90048.1	PGA1_c03170	PGA1_c03150	Hypothetical protein.	Putative acyl-CoA dehydrogenase.	0.693
AFO90050.1	AFO90049.1	PGA1_c03170	PGA1_c03160	Hypothetical protein.	Metallo-beta-lactamase-like protein.	0.811
AFO90050.1	AFO90051.1	PGA1_c03170	PGA1_c03180	Hypothetical protein.	Hypothetical protein.	0.550
AFO90050.1	AFO90052.1	PGA1_c03170	PGA1_c03190	Hypothetical protein.	Hypothetical protein.	0.516
AFO90050.1	AFO90053.1	PGA1_c03170	PGA1_c03200	Hypothetical protein.	Hypothetical protein.	0.680
AFO90051.1	AFO90048.1	PGA1_c03180	PGA1_c03150	Hypothetical protein.	Putative acyl-CoA dehydrogenase.	0.517
AFO90051.1	AFO90049.1	PGA1_c03180	PGA1_c03160	Hypothetical protein.	Metallo-beta-lactamase-like protein.	0.503
AFO90051.1	AFO90050.1	PGA1_c03180	PGA1_c03170	Hypothetical protein.	Hypothetical protein.	0.550
AFO90051.1	AFO90052.1	PGA1_c03180	PGA1_c03190	Hypothetical protein.	Hypothetical protein.	0.541
AFO90051.1	AFO90053.1	PGA1_c03180	PGA1_c03200	Hypothetical protein.	Hypothetical protein.	0.537
AFO90051.1	AFO90066.1	PGA1_c03180	PGA1_c03330	Hypothetical protein.	Tetratricopeptide repeat-containing protein.	0.544
AFO90051.1	AFO91517.1	PGA1_c03180	PGA1_c18200	Hypothetical protein.	Hypothetical protein.	0.544

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.751

expected number of edges:

10

PPI enrichment p-value:

1.85e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030433

Ubiquitin-dependent ERAD pathway

5 of 41

1.99

2.86

6.76e-07

GO:0016567

Protein ubiquitination

7 of 125

1.66

2.55

1.50e-07

GO:0010033

Response to organic substance

7 of 150

1.58

2.37

1.86e-07

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

6 of 144

1.53

2.02

2.64e-06

GO:0051603

Proteolysis involved in protein catabolic process

7 of 235

1.38

1.83

1.20e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004842

Ubiquitin-protein transferase activity

6 of 90

1.73

2.46

9.21e-07

GO:0061631

Ubiquitin conjugating enzyme activity

3 of 26

1.97

1.38

0.0020

GO:0043130

Ubiquitin binding

3 of 29

1.92

1.36

0.0020

GO:0097027

Ubiquitin-protein transferase activator activity

2 of 5

2.51

1.23

0.0056

GO:0061630

Ubiquitin protein ligase activity

3 of 52

1.67

1.09

0.0056

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000836

Hrd1p ubiquitin ligase complex

3 of 5

2.69

2.31

5.57e-05

GO:0000151

Ubiquitin ligase complex

4 of 70

1.66

1.61

0.00023

GO:0140535

Intracellular protein-containing complex

7 of 371

1.18

1.24

5.57e-05

GO:1990234

Transferase complex

5 of 340

1.08

0.8

0.0045

GO:0005783

Endoplasmic reticulum

5 of 429

0.97

0.66

0.0101

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7371

Mixed, incl. Ubiquitin-dependent ERAD pathway, and Hedgehog ligand biogenesis

5 of 40

2.0

2.69

1.91e-06

CL:604

Ubiquitin-conjugating enzyme E2

3 of 7

2.54

2.29

5.41e-05

CL:567

Mixed, incl. Ubiquitin-like protein conjugating enzyme activity, and HECT domain

4 of 45

1.86

1.98

5.99e-05

CL:7375

Ubiquitin-dependent ERAD pathway, and Hedgehog ligand biogenesis

3 of 29

1.92

1.48

0.0011

CL:13337

CCR4-NOT core complex, and Ubiquitin-protein transferase regulator activity

2 of 10

2.21

1.06

0.0105

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

7 of 168

1.53

2.39

4.77e-08

map04120

Ubiquitin mediated proteolysis

4 of 102

1.5

1.39

0.00045

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000835

ER ubiquitin ligase complex

4 of 12

2.43

2.96

2.18e-06

GOCC:0000151

Ubiquitin ligase complex

5 of 76

1.73

2.17

7.77e-06

GOCC:1990389

CUE1-UBC7 ubiquitin-conjugating enzyme complex

2 of 2

2.91

1.59

0.0013

GOCC:0005789

Endoplasmic reticulum membrane

5 of 137

1.47

1.55

9.85e-05

GOCC:0000836

Hrd1p ubiquitin ligase complex

2 of 10

2.21

1.13

0.0079

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000608

Ubiquitin-conjugating enzyme E2

3 of 23

2.02

1.06

0.0098

IPR016135

Ubiquitin-conjugating enzyme/RWD-like

3 of 28

1.94

1.04

0.0098

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00184

Ring finger

3 of 55

1.64

0.92

0.0129

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