node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Veis_1917 | Veis_2458 | Veis_1917 | Veis_2458 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | 0.965 |
Veis_1917 | Veis_3957 | Veis_1917 | Veis_3957 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | 0.994 |
Veis_1917 | Veis_4048 | Veis_1917 | Veis_4048 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | KEGG: cps:CPS_4034 sarcosine oxidase, alpha subunit; TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase); FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Glycine cleavage T-protein, C-terminal barrel; Belongs to the GcvT family. | 0.978 |
Veis_1917 | folD | Veis_1917 | Veis_1922 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.687 |
Veis_1917 | gcvH | Veis_1917 | Veis_3958 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.995 |
Veis_1917 | gcvP | Veis_1917 | Veis_3959 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.977 |
Veis_1917 | glyA | Veis_1917 | Veis_4246 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.968 |
Veis_1917 | purH | Veis_1917 | Veis_3025 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | KEGG: rfr:Rfer_1582 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.417 |
Veis_1917 | purL | Veis_1917 | Veis_3609 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.593 |
Veis_2458 | Veis_1917 | Veis_2458 | Veis_1917 | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | 0.965 |
Veis_2458 | Veis_3957 | Veis_2458 | Veis_3957 | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | 0.993 |
Veis_2458 | Veis_4048 | Veis_2458 | Veis_4048 | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | KEGG: cps:CPS_4034 sarcosine oxidase, alpha subunit; TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase); FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Glycine cleavage T-protein, C-terminal barrel; Belongs to the GcvT family. | 0.940 |
Veis_2458 | folD | Veis_2458 | Veis_1922 | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.525 |
Veis_2458 | gcvH | Veis_2458 | Veis_3958 | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.998 |
Veis_2458 | gcvP | Veis_2458 | Veis_3959 | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.989 |
Veis_2458 | glyA | Veis_2458 | Veis_4246 | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.968 |
Veis_2458 | purH | Veis_2458 | Veis_3025 | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | KEGG: rfr:Rfer_1582 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.486 |
Veis_2458 | purL | Veis_2458 | Veis_3609 | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.689 |
Veis_3957 | Veis_1917 | Veis_3957 | Veis_1917 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rfr:Rfer_2214 dihydrolipoamide dehydrogenase. | 0.994 |
Veis_3957 | Veis_2458 | Veis_3957 | Veis_2458 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | KEGG: rha:RHA1_ro08466 glycine dehydrogenase (decarboxylating) subunit 2. | 0.993 |