node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
S7S_05310 | S7S_06970 | S7S_05310 | S7S_06970 | COG3321 Polyketide synthase modules and related proteins. | Benzyl alcohol dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. | 0.551 |
S7S_05310 | S7S_15325 | S7S_05310 | S7S_15325 | COG3321 Polyketide synthase modules and related proteins. | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | 0.637 |
S7S_05310 | S7S_15460 | S7S_05310 | S7S_15460 | COG3321 Polyketide synthase modules and related proteins. | Na-solute symporter/sensory box histidinekinase; COG0591 Na+/proline symporter. | 0.654 |
S7S_05310 | bioA | S7S_05310 | S7S_17860 | COG3321 Polyketide synthase modules and related proteins. | Adenosylmethionine--8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.513 |
S7S_05310 | bioC | S7S_05310 | S7S_01805 | COG3321 Polyketide synthase modules and related proteins. | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.412 |
S7S_05310 | bioD | S7S_05310 | S7S_01810 | COG3321 Polyketide synthase modules and related proteins. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.491 |
S7S_05310 | birA | S7S_05310 | S7S_02755 | COG3321 Polyketide synthase modules and related proteins. | biotin-[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.710 |
S7S_05310 | purL | S7S_05310 | S7S_04100 | COG3321 Polyketide synthase modules and related proteins. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.469 |
S7S_06970 | S7S_05310 | S7S_06970 | S7S_05310 | Benzyl alcohol dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. | COG3321 Polyketide synthase modules and related proteins. | 0.551 |
S7S_06970 | S7S_15325 | S7S_06970 | S7S_15325 | Benzyl alcohol dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | 0.575 |
S7S_06970 | S7S_15460 | S7S_06970 | S7S_15460 | Benzyl alcohol dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. | Na-solute symporter/sensory box histidinekinase; COG0591 Na+/proline symporter. | 0.426 |
S7S_15315 | S7S_15325 | S7S_15315 | S7S_15325 | COG0642 Signal transduction histidine kinase. | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | 0.938 |
S7S_15325 | S7S_05310 | S7S_15325 | S7S_05310 | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | COG3321 Polyketide synthase modules and related proteins. | 0.637 |
S7S_15325 | S7S_06970 | S7S_15325 | S7S_06970 | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | Benzyl alcohol dehydrogenase; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. | 0.575 |
S7S_15325 | S7S_15315 | S7S_15325 | S7S_15315 | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | COG0642 Signal transduction histidine kinase. | 0.938 |
S7S_15325 | S7S_15460 | S7S_15325 | S7S_15460 | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | Na-solute symporter/sensory box histidinekinase; COG0591 Na+/proline symporter. | 0.510 |
S7S_15325 | bioA | S7S_15325 | S7S_17860 | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | Adenosylmethionine--8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.769 |
S7S_15325 | bioB | S7S_15325 | S7S_01790 | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.869 |
S7S_15325 | bioC | S7S_15325 | S7S_01805 | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.828 |
S7S_15325 | bioD | S7S_15325 | S7S_01810 | Hypothetical protein; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.931 |