STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFU35984.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (130 aa)    
Predicted Functional Partners:
SFU99574.1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase.
 
 0.999
SFU99586.1
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.997
folE
GTP cyclohydrolase I.
 
 
 0.992
SFU51169.1
Dihydrofolate synthase / folylpolyglutamate synthase.
  
 
 0.741
SFU89245.1
Dihydrofolate synthase / folylpolyglutamate synthase.
  
 
 0.741
SFU86882.1
6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase.
    
 0.739
SFU35965.1
Glycosyl transferase family 2.
       0.682
SFU66014.1
Repeat-containing protein.
     
 0.648
SFU82180.1
XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.602
SFU47029.1
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.583
Your Current Organism:
Alicyclobacillus macrosporangiidus
NCBI taxonomy Id: 392015
Other names: A. macrosporangiidus, Alicyclobacillus macrosporangiidus Goto et al. 2007, Alicyclobacillus sp. 5A239-2O-A, DSM 17980, IAM 15370, JCM 21814, strain 5-A239-2O-A
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.