Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LP43_0047Soluble lytic murein transglycosylase precursor. (646 aa)    
Predicted Functional Partners:
cca
tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
  
    0.825
cheA
Signal transduction histidine kinase CheA.
  
    0.687
LP43_0046
Chemotaxis signal transduction protein.
  
    0.658
LP43_2452
N-acetylmuramoyl-L-alanine amidase.
 
  
 0.638
pilJ
Type IV pilus biogenesis protein PilJ.
  
    0.565
pilI
Type IV pili signal transduction protein PilI.
  
    0.520
pilG
Twitching motility protein PilG.
       0.511
pilH
Twitching motility protein PilH.
       0.511
mch
N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family.
       0.510
LP43_0050
Ribosomal protein S6 glutaminyl transferase; Belongs to the RimK family.
       0.507
Your Current Organism:
Methylophaga thiooxydans
NCBI taxonomy Id: 392484
Other names: DSM 22068, M. thiooxydans, Methylophaga thiooxidans, Methylophaga thiooxydans corrig. Boden et al. 2011, VKM B-2586, strain DMS010
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