Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LP43_0194HtrA protease/chaperone protein/Serine protease (Protease DO); Belongs to the peptidase S1C family. (459 aa)    
Predicted Functional Partners:
rseA
Sigma factor RpoE negative regulatory protein RseA.
  
 
 0.844
LP43_0193
DnaJ-class molecular chaperone CbpA.
  
 0.823
infB
Translation initiation factor 2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
  
 
 0.768
LP43_0763
Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase.
    
 0.727
rpsF
SSU ribosomal protein S6p; Binds together with S18 to 16S ribosomal RNA.
   
 
 0.714
rplK
LSU ribosomal protein L11p (L12e); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
    
   0.703
rpsI
SSU ribosomal protein S9p (S16e); Belongs to the universal ribosomal protein uS9 family.
   
   0.698
rpsM
SSU ribosomal protein S13p (S18e); Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family.
   
   0.692
rplD
LSU ribosomal protein L4p (L1e); Forms part of the polypeptide exit tunnel.
    
 
 0.685
rpsP
SSU ribosomal protein S16p; Belongs to the bacterial ribosomal protein bS16 family.
  
 
   0.677
Your Current Organism:
Methylophaga thiooxydans
NCBI taxonomy Id: 392484
Other names: DSM 22068, M. thiooxydans, Methylophaga thiooxidans, Methylophaga thiooxydans corrig. Boden et al. 2011, VKM B-2586, strain DMS010
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