glmU protein (Methylophaga thiooxydans) - STRING interaction network

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glmU

N-acetylglucosamine-1-phosphate uridyltransferase/Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (454 aa)

Predicted Functional Partners:

glmM

0.985

glmS

0.967

murA

0.946

LP43_1146

0.877

LP43_1795

0.863

prs

0.862

lpxA

0.857

LP43_1797

0.856

LP43_2196

0.854

LP43_1791

0.787

Your Current Organism:

Methylophaga thiooxydans

NCBI taxonomy Id: 392484
Other names: DSM 22068, M. thiooxydans, Methylophaga thiooxidans, Methylophaga thiooxydans corrig. Boden et al. 2011, VKM B-2586, strain DMS010

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LP43_1146	LP43_1795	LP43_1146	LP43_1795	UTP--glucose-1-phosphate uridylyltransferase.	UDP-glucose dehydrogenase.	0.969
LP43_1146	glmM	LP43_1146	LP43_0992	UTP--glucose-1-phosphate uridylyltransferase.	Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.646
LP43_1146	glmU	LP43_1146	LP43_0220	UTP--glucose-1-phosphate uridylyltransferase.	N-acetylglucosamine-1-phosphate uridyltransferase/Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.877
LP43_1146	lpxA	LP43_1146	LP43_1762	UTP--glucose-1-phosphate uridylyltransferase.	Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.	0.582
LP43_1146	murA	LP43_1146	LP43_2423	UTP--glucose-1-phosphate uridylyltransferase.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.864
LP43_1791	LP43_1795	LP43_1791	LP43_1795	UDP-N-acetylglucosamine 4,6-dehydratase.	UDP-glucose dehydrogenase.	0.784
LP43_1791	LP43_1797	LP43_1791	LP43_1797	UDP-N-acetylglucosamine 4,6-dehydratase.	UDP-N-acetylglucosamine 4,6-dehydratase.	0.821
LP43_1791	glmU	LP43_1791	LP43_0220	UDP-N-acetylglucosamine 4,6-dehydratase.	N-acetylglucosamine-1-phosphate uridyltransferase/Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.787
LP43_1795	LP43_1146	LP43_1795	LP43_1146	UDP-glucose dehydrogenase.	UTP--glucose-1-phosphate uridylyltransferase.	0.969
LP43_1795	LP43_1791	LP43_1795	LP43_1791	UDP-glucose dehydrogenase.	UDP-N-acetylglucosamine 4,6-dehydratase.	0.784
LP43_1795	LP43_1797	LP43_1795	LP43_1797	UDP-glucose dehydrogenase.	UDP-N-acetylglucosamine 4,6-dehydratase.	0.802
LP43_1795	glmM	LP43_1795	LP43_0992	UDP-glucose dehydrogenase.	Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.566
LP43_1795	glmS	LP43_1795	LP43_1796	UDP-glucose dehydrogenase.	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	0.657
LP43_1795	glmU	LP43_1795	LP43_0220	UDP-glucose dehydrogenase.	N-acetylglucosamine-1-phosphate uridyltransferase/Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.863
LP43_1797	LP43_1791	LP43_1797	LP43_1791	UDP-N-acetylglucosamine 4,6-dehydratase.	UDP-N-acetylglucosamine 4,6-dehydratase.	0.821
LP43_1797	LP43_1795	LP43_1797	LP43_1795	UDP-N-acetylglucosamine 4,6-dehydratase.	UDP-glucose dehydrogenase.	0.802
LP43_1797	glmS	LP43_1797	LP43_1796	UDP-N-acetylglucosamine 4,6-dehydratase.	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	0.601
LP43_1797	glmU	LP43_1797	LP43_0220	UDP-N-acetylglucosamine 4,6-dehydratase.	N-acetylglucosamine-1-phosphate uridyltransferase/Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.856
LP43_2196	glmU	LP43_2196	LP43_0220	Phosphotransferase.	N-acetylglucosamine-1-phosphate uridyltransferase/Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.854
LP43_2196	murA	LP43_2196	LP43_2423	Phosphotransferase.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.573

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