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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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filled nodes:
a 3D structure is known or predicted
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LP43_2025Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (438 aa)    
Predicted Functional Partners:
LP43_2024
Dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.999
LP43_2026
Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex.
 
0.998
LP43_1841
Dihydrolipoamide dehydrogenase.
 
 0.992
sucC
Succinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.992
sucD
Succinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.987
LP43_0085
Mercuric ion reductase.
 0.952
LP43_0241
Glutamate synthase [NADPH] subunit alpha.
     
 0.951
LP43_2160
FAD-dependent NAD(P)-disulfide oxidoreductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 
 0.949
LP43_1045
Citrate synthase (si); Belongs to the citrate synthase family.
  
 0.937
LP43_1170
2-methylcitrate synthase; Belongs to the citrate synthase family.
  
 0.937
Your Current Organism:
Methylophaga thiooxydans
NCBI taxonomy Id: 392484
Other names: DSM 22068, M. thiooxydans, Methylophaga thiooxidans, Methylophaga thiooxydans corrig. Boden et al. 2011, VKM B-2586, strain DMS010
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