Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LP43_2416Methionine biosynthesis protein MetW. (200 aa)    
Predicted Functional Partners:
metXS
Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
 
 0.997
LP43_1219
Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family.
 
 0.885
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
       0.787
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
       0.687
LP43_2414
Integral membrane protein YggT, involved in response to extracytoplasmic stress (osmotic shock).
       0.687
LP43_2319
Hypothetical protein.
    
 0.675
thrB
Homoserine kinase; Belongs to the pseudomonas-type ThrB family.
  
     0.656
mgdC
N-methyl glutamate dehydrogenase/oxidoreductase subunit C; Belongs to the GcvT family.
     
 0.631
LP43_2412
Hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
       0.607
LP43_0476
Octaprenyl-diphosphate synthase/Dimethylallyltransferase/Geranyltranstransferase (farnesyldiphosphate synthase)/Geranylgeranyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family.
   
  0.545
Your Current Organism:
Methylophaga thiooxydans
NCBI taxonomy Id: 392484
Other names: DSM 22068, M. thiooxydans, Methylophaga thiooxidans, Methylophaga thiooxydans corrig. Boden et al. 2011, VKM B-2586, strain DMS010
Server load: low (32%) [HD]