Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Swit_0154PFAM: phage integrase family protein; Belongs to the 'phage' integrase family. (451 aa)    
Predicted Functional Partners:
Swit_0155
PFAM: protein of unknown function DUF1044.
     
 0.630
Swit_0156
Transcriptional regulator, XRE family.
       0.612
Swit_0197
Hypothetical protein.
 
   
 0.599
Swit_0559
PFAM: phosphoribosyltransferase.
  
    0.593
Swit_3007
PFAM: Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein.
  
    0.498
Swit_3104
PFAM: protein of unknown function DUF159; Belongs to the SOS response-associated peptidase family.
  
  
 0.488
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.463
Swit_0153
Transcriptional regulator, TetR family; PFAM: regulatory protein, TetR.
  
  
 0.450
Swit_0185
PFAM: protein of unknown function DUF736.
  
     0.433
Swit_1817
PFAM: Erythromycin esterase.
  
     0.430
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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