STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Swit_0177Type IV secretory pathway VirD4 components-like protein. (578 aa)    
Predicted Functional Partners:
Swit_0178
TIGRFAM: Ti-type conjugative transfer relaxase TraA; PFAM: MobA/MobL protein.
 
   
 0.908
Swit_3111
PFAM: HNH endonuclease; SMART: HNH nuclease.
   
 
 0.610
Swit_4397
Hypothetical protein.
   
 
 0.610
Swit_0179
Hypothetical protein.
     
 0.550
Swit_0180
PFAM: Conjugal transfer TraD family protein.
     
 0.526
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.459
Swit_0170
PFAM: conjugation TrbI family protein.
 
 
 
 0.456
Swit_3700
PFAM: conjugation TrbI family protein.
 
 
 
 0.448
Swit_0175
Transcriptional regulator, LuxR family; PFAM: regulatory protein, LuxR; Autoinducer-binding domain protein.
 
     0.433
Swit_0176
RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily.
       0.423
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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