Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Swit_0724Methylenetetrahydromethanopterin reductase; PFAM: luciferase family protein. (336 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.903
Swit_0415
Coenzyme F420-0 gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129.
 
   
 0.792
Swit_0414
LPPG:FO 2-phospho-L-lactate transferase; TIGRFAM: LPPG domain containing protein; PFAM: protein of unknown function UPF0052 and CofD.
 
   
 0.790
Swit_0413
Conserved hypothetical protein.
 
   
 0.763
Swit_2098
PFAM: luciferase family protein.
  
     0.741
Swit_0723
PFAM: protein of unknown function DUF1486.
       0.718
Swit_0718
TIGRFAM: NADPH-dependent F420 reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent; 6-phosphogluconate dehydrogenase, NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein.
 
  
 0.705
Swit_0725
PFAM: TonB-dependent receptor; TonB-dependent receptor, plug.
       0.654
Swit_0717
FO synthase subunit 1 / FO synthase subunit 2; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB.
 
  
 0.636
Swit_0704
PFAM: luciferase family protein.
  
     0.548
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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