Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Swit_1235PFAM: CHASE2 domain protein; Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein. (671 aa)    
Predicted Functional Partners:
Swit_1477
Putative adenylate/guanylate cyclase; TIGRFAM: PAS sensor protein; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; GAF domain protein; histidine kinase, HAMP region domain protein; PAS fold-4 domain protein; PAS fold domain protein.
 
 0.989
Swit_0231
Putative adenylate/guanylate cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2 domain protein.
 
  
 0.964
Swit_1237
PFAM: Sulfate transporter/antisigma-factor antagonist STAS.
 
 
 0.949
Swit_1492
Anti-sigma-factor antagonist; TIGRFAM: anti-anti-sigma factor; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; Belongs to the anti-sigma-factor antagonist family.
 
 
 0.924
Swit_1493
Putative anti-sigma regulatory factor, serine/threonine protein kinase.
 
 
 0.923
Swit_3527
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
    
 0.907
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
  0.903
Swit_0253
TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase.
    
  0.903
Swit_1232
Putative anti-sigma regulatory factor, serine/threonine protein kinase; PFAM: ATP-binding region, ATPase domain protein domain protein.
 
 
 0.900
Swit_1236
Metal-dependent hydrolase of the beta-lactamase superfamily I-like protein.
 
    0.835
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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