STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Swit_1600PFAM: AMP-dependent synthetase and ligase. (496 aa)    
Predicted Functional Partners:
Swit_1599
PFAM: AMP-dependent synthetase and ligase.
 
  
 
0.977
Swit_0351
PFAM: AMP-dependent synthetase and ligase.
  
  
 
0.907
Swit_1598
PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain.
  
  
 0.804
Swit_0829
TIGRFAM: benzoate-CoA ligase family; PFAM: AMP-dependent synthetase and ligase.
 
 
0.566
Swit_4371
PFAM: AMP-dependent synthetase and ligase.
 
 
0.531
rplF
LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
   
 0.530
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
 
 
 0.517
Swit_0669
PFAM: AMP-dependent synthetase and ligase.
 
0.513
Swit_3096
PFAM: ferredoxin; cytochrome P450; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein.
  
 0.490
Swit_3393
PFAM: ferredoxin; cytochrome P450; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein.
  
 0.490
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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