Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Swit_1641Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (349 aa)    
Predicted Functional Partners:
Swit_1640
Acetaldehyde dehydrogenase-like protein; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
 0.999
Swit_1639
PFAM: Hydratase/decarboxylase.
 
 
 0.995
Swit_2111
PFAM: Hydratase/decarboxylase.
 
 
 0.983
Swit_3520
PFAM: Hydratase/decarboxylase.
 
 
 0.978
Swit_0911
PFAM: Hydratase/decarboxylase.
 
 
 0.976
Swit_2112
Acetaldehyde dehydrogenase-like protein; PFAM: Semialdehyde dehydrogenase, NAD - binding; Acetaldehyde dehydrogenase-like.
 
 
 0.953
Swit_0742
2-keto-4-pentenoate hydratase-like protein.
  
 
 0.923
Swit_2113
Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
  
  
 
0.900
Swit_1643
PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase.
    
 0.829
Swit_1642
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding.
  
  
 0.801
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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