Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Swit_2234Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein. (442 aa)    
Predicted Functional Partners:
Swit_2235
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.982
Swit_2147
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.867
Swit_2540
PFAM: response regulator receiver.
   
 
 0.838
Swit_4798
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.810
Swit_2954
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.806
Swit_1954
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.802
Swit_3577
Two component transcriptional regulator, winged helix family; TIGRFAM: phosphate regulon transcriptional regulatory protein PhoB; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.794
Swit_4432
PAS/PAC sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
 
 
 
 0.786
Swit_1386
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.777
Swit_4516
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.776
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
Server load: low (6%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.