Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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[Homology]
Score
Swit_2741TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490. (223 aa)    
Predicted Functional Partners:
Swit_2745
ABC-type uncharacterized transport system auxiliary component-like protein.
 
     0.791
Swit_2744
PFAM: Mammalian cell entry related domain protein.
 
     0.779
Swit_2742
PFAM: protein of unknown function DUF140.
       0.745
Swit_2743
PFAM: ABC transporter related; SMART: AAA ATPase.
       0.745
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.701
Swit_3903
PFAM: diacylglycerol kinase, catalytic region.
 
  
 0.701
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
  
 0.693
hisB
PFAM: imidazoleglycerol-phosphate dehydratase.
  
  
 0.672
Swit_4683
PFAM: tRNA synthetase, class II (G, H, P and S).
 
    0.669
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.664
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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