Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Swit_3520PFAM: Hydratase/decarboxylase. (263 aa)    
Predicted Functional Partners:
Swit_3521
PFAM: Hydratase/decarboxylase.
 
  
 
0.981
Swit_1641
Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 
 0.978
Swit_2113
Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 
 0.978
Swit_0888
PFAM: alpha/beta hydrolase fold.
 
 
 0.934
Swit_0912
PFAM: Hydratase/decarboxylase.
  
  
 
0.919
Swit_3522
PFAM: Endoribonuclease L-PSP.
  
 
 0.888
Swit_1640
Acetaldehyde dehydrogenase-like protein; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
  
 0.849
Swit_2112
Acetaldehyde dehydrogenase-like protein; PFAM: Semialdehyde dehydrogenase, NAD - binding; Acetaldehyde dehydrogenase-like.
 
  
 0.849
Swit_3519
PFAM: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
 
  
 0.834
Swit_3524
Aminocarboxymuconate-semialdehyde decarboxylase; PFAM: amidohydrolase 2.
     
 0.787
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.