Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Swit_3863TIGRFAM: fumarylacetoacetase; PFAM: fumarylacetoacetate (FAA) hydrolase; Domain of unknown function DUF1969. (426 aa)    
Predicted Functional Partners:
hmgA
Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
 
  
 0.963
Swit_3352
TIGRFAM: maleylacetoacetate isomerase; PFAM: Glutathione S-transferase, N-terminal domain.
 
 0.959
Swit_3058
TIGRFAM: maleylacetoacetate isomerase; PFAM: Glutathione S-transferase, N-terminal domain.
 
 
 0.947
Swit_3865
TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase.
 
  
 0.916
Swit_1558
TIGRFAM: fumarylacetoacetase; PFAM: fumarylacetoacetate (FAA) hydrolase; Domain of unknown function DUF1969.
  
  
 
0.903
Swit_3060
PFAM: fumarylacetoacetate (FAA) hydrolase.
    
 0.903
Swit_1685
TIGRFAM: fumarylacetoacetase; PFAM: fumarylacetoacetate (FAA) hydrolase; Domain of unknown function DUF1969.
  
  
 
0.902
Swit_1557
PFAM: homogentisate 1,2-dioxygenase.
 
  
 0.845
fumC
Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.840
Swit_1310
TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 
  0.818
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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